concept

senescent cells

Also known as: SCs, senescent cell, senescent somatic cells

Facts (46)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 43 facts

claimSenolytics, which remove senescent cells, and senomorphics, which attenuate the senescence-associated secretory phenotype (SASP), can ameliorate diabetes and its complications by alleviating insulin resistance and reducing tissue inflammation.

claimThe increasing exhaustion and senescence of β cells with age drives diabetes, and reversing senescent β cells or enhancing their function contributes to diabetes treatment.

referenceNew agents that target senescent cells include the flavone fisetin and the BCL-XL inhibitors A1331852 and A1155463, as reported by Xu et al. in Aging (2017).

claimStrategies for tissue regeneration include the elimination of senescent cells with senolytics, exogenous stem cell transplantation to replenish the stem cell pool, the use of extracellular vesicles (EVs) and their engineered derivatives to alleviate cellular senescence, and the application of wound inflammatory and chemical compounds to rejuvenate stem cells.

referenceThe clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.

referenceGuan et al. (2011) published 'Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state' in Genes & Development, demonstrating that reprogramming can reverse aging markers in human cells.

referenceTargeting senescent cells alleviates obesity-induced metabolic dysfunction, as reported by Lee et al. in Aging Cell (2019).

claimSenolytics, which kill senescent cells and stop the bystander effects of the senescence-associated secretory phenotype (SASP), are a potential treatment for age-related macular degeneration (AMD) due to the role of cellular senescence in its pathogenesis.

claimThe interaction between the activating NKG2D receptor and its ligands expressed on senescent cells determines the involvement of natural killer (NK) cells in the elimination of those senescent cells.

claimApproaches for treating diabetes by targeting senescent β cells include novel drugs for antagonizing β cell senescence, regulating metabolic burden to protect β cell function, inhibiting islet inflammation, in vivo reprogramming for β cell regeneration, and epigenetic modifications to rejuvenate senescent β cells.

claimTargeting the inhibition of anti-apoptotic regulators is an approach used to increase the susceptibility of senescent cells (SCs) to apoptosis.

claimCellular senescence can cause inflammation and metabolic disturbances associated with obesity, and the elimination of senescent cells with senolytic interventions may help improve obesity clinically.

claimSenomorphics, also known as SASP inhibitors, target pathways such as p38 MAPK, JAK/STAT, and interleukins to attenuate the senescence-associated secretory phenotype (SASP) of senescent cells.

claimF4/80+ macrophages contribute to the clearance of senescent cells in the mouse postpartum uterus, as reported in a 2017 study published in Endocrinology.

claimPharmacological removal of senescent cells improves memory in Alzheimer’s disease by reducing brain β-amyloid load and tauopathy.

claimSenescent cell (SC) elimination and senescence-associated secretory phenotype (SASP) inhibition have demonstrated efficacy in clinical studies for treating functional degeneration and chronic diseases associated with ageing.

claimSmall interfering RNAs (siRNAs) targeting anti-apoptotic regulators in senescent cells are effective at killing those senescent cells.

measurementNicotinamide mononucleotide (NMN) alleviates retina damage, reduces DNA damage by 50%, and eliminates senescent cells (SCs) in age-related macular degeneration models.

claimTissue-resident macrophages or circulating monocytes are capable of eliminating senescent cells.

claimInhibition of USP7 activity selectively eliminates senescent cells, in part by restoring p53 activity, according to a 2020 study in Aging Cell.

referenceTanaka et al. (2020) developed a high-efficacy reprogramming method for generating human induced pluripotent stem cells from pathologic and senescent somatic cells, as published in the International Journal of Molecular Sciences.

claimThe clearance of senescent cells (SCs) is a methodology used for the treatment of osteoporosis.

referenceTakasugi et al. (2017) demonstrated that small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through the EphA2 receptor.

claimThe removal of senescent cells (SCs) is an emerging strategy with the potential to address obesity-associated metabolic dysfunction and its complications.

claimFuture research on immune clearance of senescent cells should focus on approaches such as chimeric antigen receptors (CAR), modified T-cell receptors, vaccines, and small molecule immunomodulators to enhance the selectivity and efficiency of immune cells.

referenceDirected elimination of senescent cells can be achieved by inhibition of BCL-W and BCL-XL, according to Jaijyan et al. in Nature Communications (2016).

claimSenescent cells (SCs) exhibit resistance to apoptosis, which suggests they rely on antiapoptotic, pro-survival mechanisms to prevent self-destruction.

claimThe p38MAPK inhibitors SB203580, UR-13756, and BIRB 796 potently suppress SASP expression in senescent cells.

claimClearance of senescent cells (SCs) and decreasing the senescence-associated secretory phenotype (SASP) benefit organ repair and disease treatment, but senolytics often have poor cell selectivity that may damage normal tissue, and SASP inhibitors targeting specific secretory factors have limited therapeutic effects on multiple factors-mediated diseases.

claimSenescent cell (SC) populations are heterogeneous regarding their composition, function, and tissue distribution, which complicates the transition of therapies from laboratory settings to clinical applications.

claimCD8+ cytotoxic T cells function in immune surveillance by using granular exocytosis and expressing the NKG2D receptor to identify and eliminate senescent cells.

referenceThe transcriptome of senescent cells can be used to identify senolytic drugs, as described by Yosef et al. in Aging Cell (2015).

claimTargeting senescent cells is a strategy in translational medicine.

claimPathological accumulation of senescent cells (SCs) is associated with ageing and a range of diseases, making them potential pharmacological targets for delaying the ageing process.

claimSenescent cells contribute to the pathophysiology of diabetes through their direct impact on pancreatic β-cell function, involvement in adipose tissue malfunction, and SASP-associated tissue inflammation.

claimde Keizer explored the potential of targeting senescent cells as a "fountain of youth" in a 2017 article in Trends in Molecular Medicine.

referenceZhong et al. (2021) found that invariant natural killer T cells coordinate the removal of senescent cells.

claimActivating immune cells to eliminate senescent cells improves blood glucose regulation in diabetes treatment.

claimDasatinib triggers apoptosis in senescent cells by blocking Src kinase, which interferes with dependency receptors like ephrins.

claimThe accumulation of senescent cells (SCs) during ageing accelerates the onset of ageing-related disorders and chronic diseases, including metabolic disorders, degenerative disorders, inflammation, autoimmune diseases, and cancers.

claimThe drug ABT-263 can improve kidney function and stimulate tubular proliferation to reestablish a regenerative phenotype by selectively eliminating senescent cells.

referenceSenolytics can eliminate senescent cells and alleviate intervertebral disc degeneration.

claimIn chronic wounds, the interaction between senescent cells and the extracellular matrix is a barrier to healing because senescent cells produce Senescence-Associated Secretory Phenotype (SASP) factors and Reactive Oxygen Species (ROS), which increase matrix proteolysis, cause inflammation, impair vascular endothelial cells, and create a microenvironment that accelerates further cellular senescence.

Targeting immunosenescence and inflammaging - Nature nature.com Nature Sep 1, 2025 1 fact

claimClearance of senescent cells using the drug ABT263 rejuvenates aged hematopoietic stem cells in mice.

3. The Innate Immune System - Immunopaedia immunopaedia.org.za Immunopaedia 1 fact

claimB-1 cells perform immune regulation through the synthesis of IL-10 and participate in the clearance of senescent and apoptotic cells.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 1 fact

claimPTBP1-mediated alternative splicing regulates the inflammatory secretome and the pro-tumorigenic effects of senescent cells.