Knowledge Tree
perturbation resistance potential
Also known as: PRP
Facts (24)
Sources
Allostasis revisited: A perception, variation, and risk framework frontiersin.org Sep 28, 2022 24 facts
formulaPerturbation resistance potential (PRP) is calculated as Eg – (Ee + Ei), representing the difference between allostatic load and resource availability.
claimCirculating glucocorticoid levels are likely regulated in part based on an individual’s proximity to energetic crisis, which is identified as the perturbation resistance potential (PRP).
claimTo align glucocorticoid response models with starvation physiology, the model should define Perturbation Resistance Potential (PRP) = 0 as the point where fat reserves are exhausted or insufficient to meet metabolic demands.
claimPerturbation resistance potential (PRP) can change gradually or abruptly and may be reflected by spikes in blood hormone levels.
claimAnimals may interpret stimuli previously classified as 'stressors' as cues to estimate the probability and severity of threats to their Perturbation Resistance Potential (PRP) when managing errors in decisions to engage the Emergency Life-History Stage (ELHS).
claimPerturbation resistance potential (PRP) is defined as an individual's proximity to energetic crisis, which helps regulate circulating glucocorticoid levels.
referenceNegative energy balance cues provide a direct indication of exhausted perturbation resistance potential (PRP); they are generally reliable except possibly during voluntary fasting, such as during brooding.
claimAs allostatic overload (Eo) progresses, the overall allostatic load increases and the perturbation resistance potential (PRP) decreases.
claimPerturbation resistance potential (PRP) reflects an individual's vulnerability to allostatic overload Type 1 if additional perturbations or resource limitations occur.
claimPerturbation Resistance Potential (PRP) must be measurable by both scientists and the organisms responding to the quantity to be a useful metric.
formulaPerturbation resistance potential (PRP) is calculated as the difference between cumulative resources (Ecr) and the sum of basal existence energy (Ee), routine metabolic rate (Ei), and energetic costs due to perturbation (Eo), expressed as the formula PRP = Ecr - (Ee + Ei + Eo).
claimAllostatic load indicates energetic requirements and is a reliable cue when resources are limited (allostatic load is close to Ecr, and Perturbation Resistance Potential is low), but it increases error when resources vastly exceed requirements (allostatic load is much less than Ecr, and Perturbation Resistance Potential is high).
claimThe emergency life history stage (ELHS) is triggered when perturbation resistance potential is reduced near the zero point due to environmental perturbations, extreme weather, perceived predation risk, or fear, allowing coping mechanisms while suppressing normal life history stages.
formulaPerturbation resistance potential (PRP) is a quantity in the framework of allostasis that describes the difference between allostatic load and resource availability, calculated as Eg – (Ee + Ei), and reflects an individual's vulnerability to allostatic overload Type 1.
claimIn the context of the emergency life-history stage (ELHS), stimuli traditionally labeled as 'stressors' can be reclassified as cues that animals use to assess the probability and severity of threats to their perturbation resistance potential (PRP).
claimStrategy 1 for endocrine response involves glucocorticoids gradually elevating in direct inverse correlation with the difference between allostatic load and resource availability (PRP) when PRP is low, reaching the ELHS activation threshold only when PRP equals zero.
referenceThe Reactive Scope model focuses on the physiological actions of endocrine mediators and the mechanisms by which adaptive responses indicate and generate physiological damage, excluding Eg and PRP components.
perspectiveThe authors propose examining two specific mechanisms to understand how animals inform themselves about the status of their perturbation resistance potential (PRP) and the probability of energetic crisis: (1) elevation in glucocorticoids as an endocrine 'decision,' and (2) error management strategies in evaluating responsiveness to cues.
claimNegative energy balance serves as a direct indication of exhausted Perturbation Resistance Potential (PRP) and is generally reliable, except during voluntary fasting such as during brooding.
formulaIn the model of allostatic load, perturbation resistance potential (PRP) is quantified as the difference between available resources and all energetic costs of allostatic load, including daily routines, life history stages (such as breeding, migration, and molt), and the impact of environmental perturbations.
claimPerturbation resistance potential (PRP) is a difficult metric to measure.
claimThe Perturbation Resistance Potential (PRP) is a metric used to assess an organism's physiological response to stress, but it is difficult to measure because existing research methods for estimating resource availability are imprecise and fail to account for variability in resource access, as noted by Goymann and Wingfield (2004).
claimThe article 'Allostasis revisited: A perception, variation, and risk framework' identifies allostasis, allostatic load, perturbation resistance potential, glucocorticoid, and environment as key concepts.
claimIndividual responsiveness to perturbation resistance potential (PRP) varies and influences the activation of mineralocorticoid vs glucocorticoid-type receptors, hormone metabolizing enzymes, and other downstream factors in target tissues.