concept

NF-κB signaling pathway

Also known as: NF-κB pathway, NF-kb pathways, NF-kappaB pathways, NF-kappaB pathway, NF-κB signaling pathway

Facts (10)

Sources

Medicinal plants and human health: a comprehensive review of ... link.springer.com Springer Nov 5, 2025 3 facts

referenceNotarte et al. (2023) demonstrated that a flavonol-enriched n-butanol fraction derived from the plant Uvaria alba attenuates lipopolysaccharide-induced inflammatory responses by inhibiting the NF-κB pathway and increasing NRF2 levels.

claimEndothelial dysfunction contributes to heart failure development by disrupting endothelial nitric oxide synthase (eNOS) activity, which reduces nitric oxide availability, increases reactive oxygen species production, and activates inflammatory cascades involving NF-κb signaling and the expression of adhesion molecules ICAM1 and VCAM1.

procedureThe method for inhibiting NF-κB signaling by curcuminoids and gingerols entails the inhibition of IκB kinase (IKK) complex activity and the prevention of IκB degradation, preserving NF-κB in its inactive cytoplasmic form.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 2 facts

referenceH. Yu, L. Lin, Z. Zhang, H. Zhang, and H. Hu published 'Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study' in Signal Transduction and Targeted Therapy in 2020, discussing the mechanisms and clinical applications of targeting the NF-κB pathway for disease therapy.

referenceT. Lawrence published 'The nuclear factor NF-kappaB pathway in inflammation' in Cold Spring Harbor Perspectives in Biology in 2009, which details the NF-kappaB signaling pathway in the context of inflammation.

Integrating allostasis and emerging technologies to study complex ... nature.com Nature Nov 5, 2025 2 facts

claimA study using multi-omics factor analysis reported that T lymphocytes infiltrate the chronic tumor immune microenvironment and activate the NF-κB and TNF-α pathways.

claimAcute phase HIV infection causes a rise in pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, along with activation of the NF-κB pathway.

Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us Journal of Food Science & Nutrition 2 facts

claimDehydrodiconiferyl alcohol exerts anti-inflammatory activity through inactivation of NF-kb pathways, according to Katiyar et al. [105].

referenceDehydrodiconiferyl alcohol, a compound from Silybum marianum, accelerates wound healing by inactivating NF-kappaB pathways in macrophages, according to a 2020 study by Hu et al.

Chronic inflammation in the etiology of disease across the life span nature.com Nature Dec 5, 2019 1 fact

referenceThe NF-κB pathway plays a significant role in inflammation, immunity, and cancer, as detailed by Taniguchi and Karin (2018).