concept

NF-κB

Also known as: Nuclear Factor-kappa B

Facts (14)

Sources

Medicinal plants and human health: a comprehensive review of ... link.springer.com Springer Nov 5, 2025 6 facts

measurementCurcumin, derived from Curcuma longa, diminishes TNF-α-induced NF-κB activation by 70% by directly contacting the IKK-β subunit and inhibiting upstream signaling kinases.

claimFlavonoids modulate COX-2 gene expression by inhibiting transcription factors such as NF-κB and AP-1, resulting in prolonged anti-inflammatory effects.

claimCurcuminoids and gingerols inhibit Nuclear Factor-kappa B (NF-κB) signaling pathways by inhibiting the nuclear translocation of NF-κB subunits, thereby decreasing the production of pro-inflammatory cytokines and chemokines.

claimBaicalein from Scutellaria baicalensis and luteolin from other herbs demonstrate anti-neuroinflammatory effects by regulating inflammatory pathways such as NF-κB, MAPK, and JAK-STAT signaling.

claimFlavonoids inhibit NF-κB activation and reduce viral transcription from integrated proviral DNA.

procedureThe method for inhibiting NF-κB signaling by curcuminoids and gingerols entails the inhibition of IκB kinase (IKK) complex activity and the prevention of IκB degradation, preserving NF-κB in its inactive cytoplasmic form.

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 3 facts

claimNF-κB-mediated hypothalamic immunity causes neurons to produce less gonadotropin-releasing hormone (GnRH), which contributes to age-related changes such as decreased neurogenesis, muscle weakness, skin atrophy, and bone fragility.

claimDrugs targeting senescence-associated secretory phenotype (SASP), such as glucocorticoids, resveratrol, and protease inhibitors, attenuate chronic kidney disease (CKD) primarily by inhibiting NF-κB signals and reducing reactive oxygen species (ROS).

claimTargeted inhibition of the NF-κB transcription factor may restore altered intercellular communications for rejuvenation, as age-related changes in the transcriptional landscape of tissues highlight the importance of NF-κB-induced inflammatory responses.

Antiageing strategy for neurodegenerative diseases - Nature nature.com Nature Mar 10, 2025 1 fact

referenceZhang et al. (2013) demonstrated that hypothalamic programming involving IKK-β, NF-κB, and GnRH influences systemic aging.

Integrating allostasis and emerging technologies to study complex ... nature.com Nature Nov 5, 2025 1 fact

claimA study using multi-omics factor analysis reported that T lymphocytes infiltrate the chronic tumor immune microenvironment and activate the NF-κB and TNF-α pathways.

A Comprehensive Review on the Therapeutic Properties of ... traditionalmedicine.actabotanica.org Acta Botanica 1 fact

claimCat's claw (Uncaria tomentosa) exerts anti-inflammatory actions through the modulation of NF-κB, according to a 2002 study.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 1 fact

referenceFang C, He M, Li D, Xu Q reported in Cell Signalling (2021) that YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways.

Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us Journal of Food Science & Nutrition 1 fact

claimThe anti-inflammatory mechanism of the compound involves the inhibition of iNOS, COX-2, and NF-κB signal pathways.