Knowledge Tree
music
Also known as: MuSiQue
Facts (33)
Sources
The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org 10 facts
claimMost biomedical ketamine studies do not standardize or report non-pharmacological factors, such as the presence or absence of music during treatment sessions.
claimA randomized controlled trial (RCT) investigating music with ketamine found that both music and non-music interventions were effective and tolerable in a patient population characterized by high rates of comorbidity, suicidality, and chronicity.
perspectivePsychedelic substances can magnify an individual's slight preference for a specific context (such as a musical playlist) into radically different experiences, suggesting that there is no single 'best' playlist for psychedelic therapy, but rather a best choice for a specific patient on a specific day.
procedureThe Montreal model dosing protocol allows for iterative treatment tailoring, such as enabling participants to select music for each treatment session based on their previous experiences and current preferences, rather than using a standard playlist for all patients.
claimPatients in the Montreal model report that collaborative selection of treatment elements provides direct benefits, such as music suited to the treatment, and indirect benefits, such as increased feelings of engagement and autonomy.
accountThe Montreal model of psychedelic therapy was evaluated in a randomized controlled trial (RCT) examining the effects of music on ketamine infusions in patients with treatment-resistant depression (TRD).
referenceA clinical trial titled 'Music as an intervention to improve hemodynamic tolerability of ketamine in depression' is registered on ClinicalTrials.gov (NCT04701866) as of 2023.
claimThe Montreal model of ketamine treatment incorporates patient choice regarding music selection, behavioral goals, and the nature of psychological support (such as quiet accompaniment, breathing exercises, or guided body scans) during the six treatment sessions.
procedureThe Montreal model of ketamine-assisted therapy follows a structured session course consisting of seven steps: (1) Check-in: Review recent life events, medical/psychiatric risk, symptomatic changes, treatment changes, and progress on goals. (2) Rolling integration: Discuss the previous ketamine treatment experience and its relevance to day-to-day life. (3) Establish intentions and activities: Mutually agree on goals, music, and the degree of clinician guidance. (4) Ketamine initiation: Verify baseline hemodynamic parameters, psychological readiness, and consent, then install an intravenous line and start the infusion. (5) Ketamine infusion: Conduct a brief mindfulness exercise; if using music, play a 50–60 minute playlist; if not using music, encourage openness and acceptance while monitoring blood pressure (every 10–15 min), heart rate, and oxygen saturation. (6) Debrief: Engage in a 20–30 minute discussion following the 40-minute infusion or music playlist, prioritizing validation of emotions and revisiting intentions. (7) Rolling preparation: Review and discuss plans for the subsequent days and the next treatment, including behavioral goals.
procedurePsychedelic treatment approaches typically utilize dosing regimens that involve fewer treatments at higher doses with the explicit aim of engendering powerful alterations of consciousness, which are then shaped by treatment adjuncts like music and psychological support.
Psychedelics, Sociality, and Human Evolution frontiersin.org 8 facts
claimM. Kaelen et al. provided evidence for a central role of music in psychedelic therapy in a 2018 study.
perspectivePsychedelic use may have declined in modern human societies because safer, more effective, or more convenient methods to access altered states of consciousness and support social bonding—such as music and religion—have become integral parts of the human niche.
claimThe niche-construction dynamic, involving a combination of cultural and biological selection, explains why psychedelic use is not ubiquitous while institutionalized altered states of consciousness, music, and religion are cross-cultural universals.
claimPsilocybin ingestion enhances human engagement with music and eloquence.
claimThe interpersonal and prosocial effects of psilocybin may have mediated the expansion of social bonding mechanisms such as laughter, music, storytelling, and religion, thereby favoring selection for prosociality in the human lineage.
referenceThe review 'Music, health, and well-being: a review' was published in the International Journal of Qualitative Studies on Health and Well-being in 2013.
claimEarly religious forms developed within the context of intense and immersive experiences involving music, ritual, and dance, likely combined with the use of psychedelics and other mind-altering techniques.
claimRitual chanting, music, and dance were developed to induce euphoria and ecstasy, known as altered states of consciousness (ASC), which enhance health, well-being, social bonding, and creativity even without the ingestion of psychedelics.
Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org 4 facts
claimLSD-induced alterations in the neural response to dynamic changes in music are mediated by serotonin 2A receptor signaling.
claimLSD enhances the emotional response to music.
referenceA 2017 study by Barrett, Robbin, Smooke, and Brown published in Frontiers in Psychology identified qualitative and quantitative features of music reported to support peak mystical experiences during psychedelic therapy sessions.
referenceA 2018 review by Barrett, Preller, and Kaelen explored the neuroscience and therapeutic implications of the relationship between psychedelics and music.
EdinburghNLP/awesome-hallucination-detection - GitHub github.com 3 facts
referenceSQuAD, Natural Questions, and MuSiQue are datasets that utilize F-1 and Exact Match metrics for classification and token-level evaluation.
claimFuzzyQA is a dataset based on HybridDialogue and MuSiQue where complex questions were simplified using ChatGPT.
measurementEvaluation metrics for hallucination detection and knowledge consistency include MC1, MC2, and MC3 scores for the TruthfulQA multiple-choice task; %Truth, %Info, and %Truth*Info for the TruthfulQA open-ended generation task; subspan Exact Match for open-domain QA tasks (NQ-Open, NQ-Swap, TriviaQA, PopQA, MuSiQue); accuracy for MemoTrap; and Prompt-level and Instruction-level accuracies for IFEval.
The Mechanisms of Psychedelic Visionary Experiences - Frontiers frontiersin.org Sep 27, 2017 2 facts
claimMichael Winkelman demonstrated that the mimetic complex of dance, music, drumming, and rhythmic enactment served as the context for transforming the collective rituals of ancient hominins into the visionary rituals of shamanism.
claimExpressive manifestations of mimesis, such as dance, music, and ritual, provided a publicly accessible system of meaning for early humans.
Large Language Models Meet Knowledge Graphs for Question ... arxiv.org Sep 22, 2025 1 fact
referenceThe LPKG method, proposed by Wang et al. in 2024, involves Planning LLM Tuning, Inference, and Execution using GPT-3.5-Turbo, CodeQwen1.5-7B-Chat, and Llama-3-8B-Instruct models with dataset-inherent knowledge graphs (Wikidata) and Wikidata15K for KGQA and Multi-hop QA, evaluated using EM, P, and R metrics on the HotpotQA, 2WikiMQA, Bamboogle, MuSiQue, and CLQA-Wiki datasets.
Neuroimaging in psychedelic drug development: past, present, and ... nature.com Sep 27, 2023 1 fact
claimPsilocybin therapy for depression is associated with increased low-frequency brain responses to music, according to a 2023 study.
Something Rich and Strange: Rabindranath Tagore (1861-1941 ... smuralis.wordpress.com Apr 16, 2012 1 fact
quotePoet, Singer
Through music the world as I see,
I know it, reveals its intimacy.
Psychedelic Drugs News - ScienceDaily sciencedaily.com 1 fact
claimHigh-ventilation breathwork combined with music can evoke psychedelic-like states, shifting blood flow in the brain and reducing negative emotions, with participants reporting experiences of unity and bliss.
Classification Schemes of Altered States of Consciousness - ORBi orbi.uliege.be 1 fact
referenceKaelen et al. (2015) found that LSD enhances the emotional response to music, as published in Psychopharmacology.
Business ecosystems as a way to activate lock-in in business models link.springer.com Mar 28, 2025 1 fact
referenceVoigt, Buliga, and Michl published the chapter 'Passion for music: The case of Spotify' in the book 'Business Model Pioneers: How Innovators Successfully Implement New Business Models' in 2017.