Knowledge Tree
multiple sclerosis
Also known as: MS
Facts (25)
Sources
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 16 facts
claimIn insulin-dependent diabetes mellitus (IDDM), the immune response targets the insulin-producing β-cells of the pancreas; in multiple sclerosis (MS), it targets myelin-producing cells of the central nervous system; in systemic lupus erythematosis (SLE), it targets multiple tissues and organs; and in rheumatoid arthritis (RA), it targets collagen-producing cells of the joints.
claimVitamin D deficiency has been implicated in the development of autoimmune diseases, including insulin-dependent diabetes mellitus (IDDM), multiple sclerosis (MS), systemic lupus erythematosis (SLE), and rheumatoid arthritis (RA).
referenceDuan S, Lv Z, Fan X, et al. published 'Vitamin D status and the risk of multiple sclerosis: a systematic review and meta-analysis' in Neuroscience Letters in 2014 (volume 570, pages 108-113), reporting on the relationship between Vitamin D status and multiple sclerosis risk.
claimLow serum 25-hydroxyvitamin D3 concentrations in individuals with IDDM, MS, and SLE are associated with increased disease activity and relapse rates.
referenceA 2013 meta-analysis by James E, Dobson R, Kuhle J, Baker D, Giovannoni G, and Ramagopalan SV published in Multiple Sclerosis examined the effect of vitamin D-related interventions on multiple sclerosis relapses.
referenceA 2011 meta-analysis by Simpson S Jr, Blizzard L, Otahal P, Van der Mei I, and Taylor B published in the Journal of Neurology, Neurosurgery & Psychiatry found that latitude is significantly associated with the prevalence of multiple sclerosis.
claimA 2013 systematic review reported no effect of vitamin D supplementation on Multiple Sclerosis relapse.
referenceDörr J, Ohlraun S, Skarabis H, and Paul F published a study protocol in 2012 in the journal Trials for a randomized controlled trial investigating the efficacy of vitamin D supplementation in patients with multiple sclerosis, known as the EVIDIMS Trial.
referenceMunger KL and Ascherio A published an article in 2011 in the journal Multiple Sclerosis discussing the prevention and treatment of multiple sclerosis through the study of vitamin D effects.
referencevan der Mei IA, Ponsonby AL, Dwyer T, et al. published a study in the Journal of Neurology in 2007 comparing vitamin D levels in people with multiple sclerosis and community controls in Tasmania, Australia.
referenceMunger KL, Zhang SM, O'Reilly E, et al. published a study in Neurology in 2004 regarding vitamin D intake and the incidence of multiple sclerosis.
referenceMunger KL, Levin LI, Hollis BW, Howard NS, and Ascherio A published a study in JAMA in 2006 regarding serum 25-hydroxyvitamin D levels and the risk of multiple sclerosis.
claimLow vitamin D intake is associated with an increased risk of Multiple Sclerosis (MS), Insulin-Dependent Diabetes Mellitus (IDDM), and Rheumatoid Arthritis (RA).
measurementA 2013 meta-analysis of five randomized controlled trials, involving 129 patients and 125 controls, found no significant effect of high-dose vitamin D supplements on the risk of relapse in Multiple Sclerosis patients.
referenceOzgocmen S, Bulut S, Ilhan N, Gulkesen A, Ardicoglu O, and Ozkan Y published a study in the Journal of Bone and Mineral Metabolism in 2005 on vitamin D deficiency and reduced bone mineral density in multiple sclerosis patients, specifically examining the effect of ambulatory status and functional capacity.
referencePozuelo-Moyano B, Benito-Leon J, Mitchell AJ, and Hernandez-Gallego J published a systematic review in Neuroepidemiology in 2013 of randomized, double-blind, placebo-controlled trials examining the clinical efficacy of vitamin D in multiple sclerosis.
Neuroanatomy, Neuron Action Potential - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 3 facts
procedureDiagnosis of Multiple Sclerosis (MS) can be aided by testing for oligoclonal bands of IgG in cerebrospinal fluid using electrophoresis.
claimMultiple sclerosis (MS) is a disease that destroys oligodendrocytes, which are responsible for maintaining the fatty myelin sheath, leading to the loss of myelin, the breakdown of neuronal axons, and the prevention of effective electrical signal carriage.
claimMultiple sclerosis (MS) commonly presents in white young adult females with symptoms including diplopia, blindness, muscle weakness, speech problems, tremors, incontinence, and vertigo.
Editorial: Inflammation and chronic disease - Frontiers frontiersin.org Jul 1, 2024 1 fact
claimHigh-sugar diets negatively impact autoimmune conditions, including rheumatoid arthritis, multiple sclerosis, psoriasis, and inflammatory bowel disease, due to pro-inflammatory effects.
How to reduce inflammation in the body - MD Anderson Cancer Center mdanderson.org Mar 20, 2026 1 fact
claimAutoimmune disorders, including rheumatoid arthritis, inflammatory bowel disease (Crohn’s disease and ulcerative colitis), psoriasis, and multiple sclerosis, are driven by inappropriate chronic inflammatory responses.
Evolutionary Eating — What We Can Learn From Our Primitive Past todaysdietitian.com Apr 1, 2009 1 fact
claimAn increasing body of evidence suggests that diet acts as an environmental trigger for autoimmune diseases, such as type 1 diabetes, multiple sclerosis, rheumatoid arthritis, and psoriasis, in genetically susceptible individuals, with the dietary factors being foods introduced after the advent of agriculture.
Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov 1 fact
claimSecondary cases of narcolepsy or hypersomnia can occur in the context of psychiatric disorders (e.g., depression), central nervous system tumors (notably in the hypothalamus), neurodegenerative disorders (e.g., Parkinson’s disease), inflammatory disorders (e.g., multiple sclerosis or paraneoplastic syndromes), traumatic disorders (e.g., head trauma), vascular disorders (e.g., median thalamic stroke), and genetic disorders (e.g., myotonic dystrophy or Prader-Willi syndrome).
What is Inflammation? Causes, Effects, Treatment - Harvard Health health.harvard.edu Mar 27, 2023 1 fact
claimAutoimmune diseases, including type 1 diabetes, rheumatoid arthritis, lupus, psoriasis, inflammatory bowel disease, and multiple sclerosis, are known to cause chronic inflammation.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 1 fact
referenceBarcelos IP, Troxell RM, and Graves JS (2019) investigate the link between mitochondrial dysfunction and multiple sclerosis.