concept

mTORC1

Also known as: mTORC1, mTORC1 protein, TORC1

Facts (7)

Sources

Psychedelics, Sociality, and Human Evolution frontiersin.org Frontiers 2 facts

claimDe Gregorio et al. (2021b) found that Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in excitatory neurotransmission, published in the Proceedings of the National Academy of Sciences of the U.S.A.

claimDe Gregorio et al. (2021b) demonstrated that repeated administration of low doses of LSD in mice enhances social interaction by potentiating 5-HT2A and AMPA receptor neurotransmission in the medial prefrontal cortex via increased phosphorylation of the mTORC1 protein.

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 2 facts

claimMetformin directly inhibits mTORC1 to improve stemness and alleviate senescence in stem cells, such as reversing aging-associated characteristics in intestinal stem cells.

claimRapamycin suppresses mTORC1, which slows the aging of mouse long-term stem cells (LT-HSCs) by maintaining their ability to self-renew and produce blood cells.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 2 facts

claimmTORC1 and mTORC2 have distinct regulatory mechanisms and metabolic functions.

claimmTORC1 regulates metabolism and disease through nutrient sensing and signaling.

Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org Genes & Development 1 fact

claimCaloric restriction promotes mTORC1-dependent enhanced self-renewal in intestinal stem cells, primarily through changes induced by the Paneth cell niche.