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mitogen-activated protein kinase (MAPK) signaling pathway
Also known as: MAPK signaling pathways, MAPK signalling pathway, MAPK pathway, MAPK signaling cascade, MAPK/ERK signaling pathway, MAPK signaling pathway, MAPK-ERK 1/2 pathway
Facts (5)
Sources
Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us 3 facts
claimSilymarin inhibits growth and induces apoptosis in AGS human gastric cancer cells by modulating the MAPK signalling pathway, as reported by Kim SH et al. in 2019.
claimSilybin induces autophagy in breast cancer via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3; it also prevents TPA and PMA induced MMP-9 expression and VEGF secretion via inactivation of the Raf/MEK/ERK pathway and blockade of AP-1 activation via MAPK signaling pathways, according to Wang et al. [101].
claimSilymarin inhibits gastric cancer growth and apoptosis through modulation of the MAPK signaling pathway, according to Kim et al. [97].
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 1 fact
claimGinsenoside 20 (R)-Rg3 enhances natural killer cell activity by increasing activating receptor expression through the MAPK/ERK signaling pathway, according to Lee et al. (2022).
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 1 fact
referenceFang C, He M, Li D, Xu Q reported in Cell Signalling (2021) that YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways.