Knowledge Tree
mitochondrial dynamics
Facts (9)
Sources
Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Apr 16, 2018 7 facts
referencePrieto and Torres (2017) reviewed the role of mitochondrial dynamics in cell reprogramming and cancer.
claimMitochondrial dynamics is the process of modulating the mitochondrial network through continuous cycles of mitochondrial fusion and fission.
claimMitochondrial dynamics allow cells to rapidly respond to environmental cues and adapt their bioenergetic needs.
referenceThe research community is currently investigating several key questions regarding stem cell homeostasis: (i) Does mitochondrial impairment affect stem cell function in vivo, and can stem cells be a therapeutic target for diseases causing mitochondrial dysfunction? (ii) Is it possible to modulate cell fate identity only through metabolic-related changes, and are these mechanisms relevant in vivo? (iii) Can the relationship between energy metabolism, cellular proliferation, and mitochondrial dynamics be untangled? (iv) What is the importance of calcium balance for cell fate plasticity? (v) How can redox homeostasis be effectively targeted to enhance stem cell function and improve efficient differentiation?
referenceMitochondrial dynamics impact stem cell identity and fate decisions by regulating a nuclear transcriptional program, according to Khacho et al. (2016).
referenceMitochondrial dynamics regulate the commitment of murine mesenchymal stem cells to differentiation, according to Forni et al. (2016).
claimBCL-2 family members contribute to the regulation of mitochondrial dynamics, which is relevant because cellular apoptosis typically involves mitochondrial fission.
Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us 1 fact
claimSilybin reduces the migratory and adhesive capacities of MDA-MB-231 breast cancer cells by affecting levels of b1-integrin and downstream molecules Cdc42, Raf-1, and D4GDI, and impairs mitochondrial dynamics and biogenesis, according to Sharifi et al. [102].
Integrating allostasis and emerging technologies to study complex ... nature.com Nov 5, 2025 1 fact
referenceBrivio et al. (2022) published research in Translational Psychiatry outlining how metabolomic signatures and mitochondrial dynamics differentiate vulnerability from resilience to chronic stress.