concept

mitochondrial DNA

Also known as: mtDNA

Facts (14)

Sources

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 6 facts

referenceLee WTY and St. John JC proposed in 2016 that mitochondrial DNA acts as an initiator of tumorigenesis.

claimMitochondrial DNA (mtDNA) mutagenesis impairs the derivation of induced pluripotent stem cells (iPSCs).

claimThe use of various antioxidants failed to increase the efficiency of induced pluripotent stem cell (iPSC) reprogramming and did not ameliorate growth defects in iPSCs carrying mitochondrial DNA (mtDNA) mutations.

claimIncreased reactive oxygen species (ROS) levels and mitochondrial DNA (mtDNA) mutagenesis lead to defective neural stem cells (NSCs) and hematopoietic stem cells (HSCs).

claimMitochondrial DNA (mtDNA) is particularly susceptible to oxidative stress due to its proximity to free radicals and the lack of histones.

claimPluripotent stem cells (PSCs) and cancer cells may maintain low levels of mitochondrial DNA (mtDNA) replication by reducing the activity of the nuclear-encoded mitochondrial polymerase gamma A (POLGA) through hypermethylation at its exon 2.

Comparable Ages for the Independent Origins of Electrogenesis in ... journals.plos.org PLOS ONE 4 facts

claimThe mitochondrial DNA sequence content and order in the 70 teleost species analyzed are typical of those found in most other teleosts.

procedureThe study used the mitochondrial DNA sequence of Amia calva (Amiiformes) to root the phylogenetic tree.

referenceLavoué et al. published detailed descriptions of the standard laboratory protocols for the long and short PCR reactions used to obtain complete mitochondrial DNA sequences from 95% ethanol-preserved fin and muscle tissue.

measurementThe researchers obtained 17 complete or nearly complete mitochondrial DNA sequences (mt-seqs) of African and South American electric fishes for the study.

Homeostatic medicine: a strategy for exploring health and disease link.springer.com Springer Sep 26, 2022 2 facts

measurementA nucleated human cell containing 1000 mitochondria is estimated to contain an average of 2000–10,000 copies of mitochondrial DNA (mtDNA).

claimRedundant mitochondrial DNA provides a reserve capacity that can reduce the impact of mutations on energy metabolism, according to Miller et al. (2003).

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 1 fact

claimSharma, Pasala, and Prakash (2019) examine the relationship between mitochondrial DNA, epigenetics, and environmental factors.

Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov National Library of Medicine 1 fact

referenceZhang X, Wu X, Hu Q, Wu J, Wang G, Hong Z, and Ren J (2019) examine the role of mitochondrial DNA in liver inflammation and oxidative stress.