Knowledge Tree
LPS
Facts (10)
Sources
Vernonia amygdalina: a comprehensive review of the ... frontiersin.org 6 facts
measurementVernonioside V suppresses the production of TNF-a, IL-6, and IL-8 inflammatory cytokines in LPS-activated Raw 264.7 cells at a dose of 30 mg/mL.
measurementVernoamyoside D inhibits nitric oxide production by 37.6% in LPS-induced RAW264.7 macrophages at 50 µM, while the positive control N-monomethylL-arginine exhibits 57.34% inhibition.
measurementVernoamyoside C inhibits nitric oxide production by 50.0% in LPS-induced RAW264.7 macrophages at 50 µM, while the positive control N-monomethylL-arginine exhibits 57.34% inhibition.
claimCynaroside (Luteolin-7-O-gluc-glucopyranoside) does not exhibit an anti-inflammatory effect on LPS-induced Raw 264.7 cells, as cytokine levels did not decrease.
measurementVernoamyoside B inhibits nitric oxide production by 24.5% in LPS-induced RAW264.7 macrophages at 50 µM, while the positive control N-monomethylL-arginine exhibits 57.34% inhibition.
measurementVernoamyoside A inhibits nitric oxide production by 20.5% in LPS-induced RAW264.7 macrophages at 50 µM, while the positive control N-monomethylL-arginine exhibits 57.34% inhibition.
Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us 1 fact
measurement(3S,5R,10S)-3-[(β-D-glucopyranosyl)oxy]-labd-8,13-dien-16,15-olide and (3S,5R,10S)-3-hydroxy-labd-8,13-dien-16,15-olide from Vitex negundo Linn. inhibit LPS-induced NO production, with the former compound acting as the strongest inhibitor with an IC50 value of 15.8 ± 1.38 µm, and both compounds significantly inhibiting IL-1β and IL-6 levels.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 1 fact
referenceFang C, He M, Li D, Xu Q reported in Cell Signalling (2021) that YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 1 fact
measurementCurcumin at dosages of 10–50 μM reduces microglial activation by 60–80% in LPS-stimulated mice, while resveratrol achieves comparable effects at 25–100 μM, according to Shahrajabian and Sun (2024).
3. The Innate Immune System - Immunopaedia immunopaedia.org.za 1 fact
claimMyeloid dendritic cells respond to bacterial infections by recognizing lipopolysaccharide (LPS) via cell-surface TLR4 and producing IL-12 and TNF-α.