Knowledge Tree
lifespan
Facts (16)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 7 facts
claimHodge B. A. et al. found that dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster, as reported in a 2022 study in Nature Communications.
claimQuantification of proteomic alterations reveals aging protein waves across the lifespan, such as the downregulation of structural pathways like the extracellular matrix (ECM) at a young age and their increase in middle and old age.
referenceChaleckis et al. (2019) observed undulating changes in human plasma proteome profiles across the lifespan.
claimExercise activates the immune system, facilitates DNA repair processes, maintains metabolic homeostasis, and lowers the risk of diabetes, obesity, cancer, osteoporosis, Alzheimer's disease, and depression, while also prolonging lifespan.
referenceSenolytics improve physical function and increase lifespan in old age, according to Chang et al. in Nature Medicine (2018).
claimHeterochronic parabiosis is used as an experimental system to examine systemic influences on lifespan, age-related diseases, and organismal aging.
referenceThe chronobiotics KL001 and KS15 extend lifespan and modify circadian rhythms of Drosophila melanogaster, as reported by Solovev, Shaposhnikov, and Moskalev in Clocks & Sleep in 2021.
Sleep Across the Lifespan: A Neurobehavioral Perspective link.springer.com Feb 5, 2025 3 facts
referenceClawson BC, Durkin J, and Aton SJ published 'Form and function of sleep spindles across the lifespan' in Neural Plasticity in 2016.
perspectiveUnderstanding the interplay between circadian physiology and the organization of body physiology across the lifespan, including neural reorganization, hormonal expression, and stress levels, is crucial for identifying optimal intervention times for positive health impacts.
referenceLee and Baker (2018) reviewed sleep and women's health across the lifespan in Sleep Medicine Clinics.
3 ways the moon affects wildlife discoverwildlife.com 1 fact
measurementThe marine annelid worm Platynereis dumerilii has a lifespan of approximately seven months.
Modern Diet and its Impact on Human Health - Longdom Publishing longdom.org 1 fact
claimNutrition, specifically the sensing and absorption of energy substances, controls aging and lifespan in addition to influencing the intensity of life activities and energy storage.
Latest advances in aging research and drug discovery aging-us.com 1 fact
claimMetformin improves healthspan and lifespan in mice, as reported in a 2013 study published in Nature Communications.
Psychedelic Drugs News - ScienceDaily sciencedaily.com 1 fact
measurementEmory University researchers discovered that psilocin, the active metabolite of psychedelic mushrooms, can delay cellular aging and extend lifespan, with human cells living over 50% longer and treated mice living 30% longer.
Western pattern diet - Wikipedia en.wikipedia.org 1 fact
referenceThe study 'Source of Dietary Carbohydrate Affects Life Span of Fischer 344 Rats Independent of Caloric Restriction' by Murtagh-Mark et al. (1995) found that the source of dietary carbohydrates affects the lifespan of Fischer 344 rats independently of caloric restriction.
Chronic inflammation in the etiology of disease across the life span nature.com Dec 5, 2019 1 fact
claimSocial stress has been shown to shorten the lifespan of mice, according to a 2018 study published in Aging Cell.