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Heterochronic parabiosis
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Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 7 facts
accountIn 2005, researchers demonstrated that heterochronic parabiosis reverses age-dependent loss in stem cell function by restoring the proliferation and regeneration capacity of aged satellite cells and hepatic progenitor cells in naturally aged mice.
referenceMa et al. (2022) reported that heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues.
claimHeterochronic parabiosis serves as an experimental system for studying systemic regulation of cell and tissue aging and identifying therapeutic opportunities for organismal rejuvenation.
claimHeterochronic parabiosis is used as an experimental system to examine systemic influences on lifespan, age-related diseases, and organismal aging.
claimIn the central nervous system, heterochronic parabiosis experiments showed that young mice exposed to an old systemic environment or plasma from old mice exhibit diminished synaptic plasticity and impaired contextual fear conditioning, spatial learning, and memory, while systemic infusion of young blood plasma reverses these effects.
claimHeterochronic parabiosis experiments identified β2-microglobulin (B2M) as a circulating factor that damages adult hippocampal regeneration and cognitive performance in an aging-dependent manner.
claimHeterochronic parabiosis studies identified GDF11 as having potential therapeutic value for age-related cardiac hypertrophy and age-dependent deterioration of the neurogenic niche.