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functional connectivity
Also known as: Functional connectivity analysis
Facts (27)
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A Synergistic Workspace for Human Consciousness Revealed by ... elifesciences.org 4 facts
referenceThe study 'High-amplitude cofluctuations in cortical activity drive functional connectivity' was published in the Proceedings of the National Academy of Sciences of the United States of America (volume 117, pages 28393–28401).
claimDeco et al. used transfer entropy as a measure of functional connectivity to assess the directionality of information exchange in the brain's global workspace.
claimThe Integrated Information Decomposition framework allows for the identification of information-theoretic components of integrated information, providing insights into human consciousness that were not captured by standard functional connectivity methods.
claimTraditional measures of statistical association, known as functional connectivity, cannot disentangle synergy and redundancy, and predominantly reflect redundant interactions.
Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org 3 facts
claimPsilocybin acutely alters the functional connectivity of the claustrum with brain networks that support perception, memory, and attention.
referenceThe study 'The Acute Effects of the Atypical Dissociative Hallucinogen Salvinorin A on Functional Connectivity in the Human Brain' by M. K. Doss, D. G. May, M. W. Johnson, J. M. Clifton, S. L. Hedrick, T. E. Prisinzano, and R. Griffiths was published in Scientific Reports in 2020.
referenceA 2017 study by Barrett, Johnson, and Griffiths published in Drug and Alcohol Dependence examined the effects of psilocybin on long-term meditators, specifically regarding default mode network functional connectivity and retrospective ratings of qualitative experience.
Protocol for testing global neuronal workspace and integrated ... journals.plos.org 3 facts
procedureTo test functional connectivity predictions, the researchers will calculate spike-LFP pairwise phase consistency for each area pair, comparing consistency at pre-stimulus onset (0–250 ms) with consistency during the stimulus onset window (250–500 ms post-stimulus onset for non-human primates; 150–400 ms post-stimulus onset for mice) and the stimulus duration window.
claimGlobal Neuronal Workspace Theory (GNWT) predicts increased functional connectivity between the prefrontal cortex (PFC), posterior parietal cortex (PPC), and sensory regions during ignition post-stimulus onset and offset.
procedureResearchers use pairwise phase consistency between brain regions to evaluate changes in functional connectivity when testing theories of consciousness.
Adversarial testing of global neuronal workspace and ... - Nature nature.com Apr 30, 2025 2 facts
referenceThe paper 'Frites: a Python package for functional connectivity analysis and group-level statistics of neurophysiological data' by Combrisson, E., Basanisi, R., Cordeiro, V. L., Ince, R. A. A., and Brovelli, A. was published in the Journal of Open Source Software, volume 7, 3842, in 2022.
procedureFunctional connectivity analysis (PPC) for both iEEG and MEG was computed between category-selective time series (face-selective and object-selective) and either V1/V2 or PFC time series.
The Mechanisms of Psychedelic Visionary Experiences - Frontiers frontiersin.org Sep 27, 2017 2 facts
referenceJiang et al. (2017) investigated brain activity and functional connectivity associated with hypnosis.
referenceThe paper 'The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers' by L. Roseman, R. Leech, A. Feilding, D. Nutt, and R. Carhart-Harris, published in Frontiers in Human Neuroscience in 2014, investigates the neurological impact of psilocybin and MDMA.
Psychedelics Assessed In New Virtual Clinical Trial - EMJ emjreviews.com Nov 27, 2025 2 facts
claimIn patients with unresponsive wakefulness syndrome, the response to simulated psychedelic use correlated with structural connectivity, whereas in minimally conscious state patients, the response was linked to the efficiency of functional connectivity.
claimMinimally conscious patients with strong functional connectivity may benefit most from psychedelic interventions, according to the findings of the virtual clinical trial.
Psychedelics and Consciousness: Distinctions, Demarcations, and ... ouci.dntb.gov.ua 2 facts
Psychedelics, Sociality, and Human Evolution frontiersin.org 1 fact
claimChanges in brain activity and connectivity induced by psychedelics lead to a flexible, functionally more connected brain during the psychedelic state.
Theories and Methods of Consciousness biomedres.us Jan 29, 2024 1 fact
quoteChen et al. state: “The energetic-metabolic processes focusing on [adenosine triphosphate] ATP, glucose, and γ -aminobutyrate/ glutamate are [also] indispensable for functional connectivity (FC) of normal brain networks that renders consciousness possible.”
Ancient Roots of Today's Emerging Renaissance in ... link.springer.com 1 fact
referenceFrederick Barrett, Samuel Krimmel, Roland Griffiths, David Seminowicz, and Brian Mathur found that psilocybin acutely alters the functional connectivity of the claustrum with brain networks involved in perception, memory, and attention.
A virtual clinical trial of psychedelics to treat patients with disorders ... eurekalert.org Nov 24, 2025 1 fact
quote“The results of the study suggest that if this treatment was to be carried out in real clinical settings, the type of patients who would most likely benefit would be an MCS patient with a strongly connected functional connectivity. This provides a starting point to target potential future clinical trials.”
Neuroimaging in psychedelic drug development: past, present, and ... nature.com Sep 27, 2023 1 fact
referenceK.H. Preller, P. Duerler, J.B. Burt, J.L. Ji, B. Adkinson, P. Stämpfli, et al. published 'Psilocybin Induces Time-Dependent Changes in Global Functional Connectivity' in Biological Psychiatry in 2020.
Altered states of consciousness – Knowledge and References taylorandfrancis.com 1 fact
referenceIn a 2016 study, Jiang et al. used functional MRI (fMRI) to examine brain activity and functional connectivity in 57 individuals grouped by high versus low hypnotizability using the Harvard Group Scale for Hypnotic Susceptibility, with participants undergoing scanning in four states: resting, memory retrieval, and two different hypnotic experiences.
Disruption of thalamic functional connectivity is a neural correlate of ... pmc.ncbi.nlm.nih.gov 1 fact
claimUnconsciousness is associated with decreased thalamic cerebral metabolic rate of glucose (CMRglc), regional cerebral blood flow (rCBF), and functional connectivity to the Default Mode Network (DMN), according to the study 'Disruption of thalamic functional connectivity is a neural correlate of...'.
The Difference Between Men and Women: Is It All in the Brain? southernregionalahec.org 1 fact
claimA study using MRI scans found that female fetuses possess neurological connections, referred to as functional connectivity, that are almost nonexistent in male brains.
The New Field of Network Physiology: Building the Human ... frontiersin.org 1 fact
claimResearch in Network Physiology has provided insights into the structural and functional connectivity of physiologic networks that underlie individual organ systems and their sub-systems.