Knowledge Tree
extracellular matrix
Also known as: ECM
Facts (18)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 11 facts
claimQuantification of proteomic alterations reveals aging protein waves across the lifespan, such as the downregulation of structural pathways like the extracellular matrix (ECM) at a young age and their increase in middle and old age.
referenceThe extracellular matrix plays a central role in aging and osteoarthritis, according to Rahmati et al. in their research.
referenceThe extracellular matrix composition and functions are detailed in a 2021 FEBS Journal guide by Karamanos et al.
referenceSchuler et al. (2021) reported that extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality.
claimIntegrin receptor-mediated cell adhesion to the extracellular matrix is necessary for cell cycle progression, specifically during the G2 to M transition and early mitosis.
claimRasouli M., Rahimi A., Soleimani M., and Keshel S. H. analyzed the interplay between the extracellular matrix and progenitor/stem cells during wound healing in a 2021 study published in Acta Histochemica.
claimDraicchio F. et al. identified the involvement of the extracellular matrix and integrin signalling proteins in skeletal muscle glucose uptake in a 2022 study published in The Journal of Physiology.
claimTargeted inhibition of metabolic processes such as glycolysis, glutaminolysis, and fatty acid oxidation can regulate collagen production, reduce extracellular matrix (ECM) accumulation, and alleviate the progression of fibrosis.
claimThrough mechano-transduction, mechanical cues from the extracellular matrix are transformed into biochemical signals that influence immune cell functions, including cell activation, cytokine generation, metabolism, proliferation, and trafficking.
claimSenescence-associated secretory phenotype (SASP) can contribute to angiogenesis, facilitate tumor development, induce epithelial-mesenchymal transition (EMT) in neighboring cancer cells, and induce extracellular matrix (ECM) degradation, which results in the migration and metastasis of cancer cells.
claimIn chronic wounds, the interaction between senescent cells and the extracellular matrix is a barrier to healing because senescent cells produce Senescence-Associated Secretory Phenotype (SASP) factors and Reactive Oxygen Species (ROS), which increase matrix proteolysis, cause inflammation, impair vascular endothelial cells, and create a microenvironment that accelerates further cellular senescence.
Thinking about the action potential: the nerve signal as a window to ... frontiersin.org 2 facts
claimThe key elements of the nanofibrous cytoskeleton, which include actin-based microfilaments, intermediate or neurofilaments, and microtubules, are connected through the cell membrane to the fibrous protein-based building blocks of the extracellular matrix.
claimCellular assemblies in tissues, organs, and the whole body are considered to represent a continuous fibrous communication network where cytoskeletal fibrillar elements connect cell nuclei and other organelles to the extracellular matrix to integrate intracellular signaling.
Healthy vs. Infected Wounds: A Clinician's Guide - Net Health nethealth.com Jun 24, 2025 1 fact
claimBacterial infection increases the production of matrix metalloproteinases (MMPs), which are enzymes that break down the extracellular matrix, leading to the degradation of newly formed collagen and other necessary extracellular matrix components.
7.8 Homeostasis and Feedback - Human Biology humanbiology.pressbooks.tru.ca 1 fact
claimA tissue is an ensemble of similar cells and their extracellular matrix from the same origin that together carry out a specific function.
Understanding the Stages of Wound Healing healogics.com 1 fact
claimFibroplasia is the process where fibroblasts produce collagen and extracellular matrix to synthesize the structural framework for new tissue.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 1 fact
claimSecondary metabolites, including catechins, proanthocyanidins, and ellagic acid, inhibit matrix metalloproteinases (MMPs) from degrading the extracellular matrix and invading tumors.
The Four Stages of Wound Healing woundevolution.com 1 fact
claimGranulation tissue is an extracellular matrix consisting of newly-generated connective tissues and blood vessels designed to replace damaged tissues.