concept

DOI

Also known as: 2,5-Dimethoxy-4-iodoamphetamine

Facts (14)

Sources

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer Dec 19, 2024 10 facts

claimIn experiments using the Open Field test, 5 mg/kg of DOI failed to boost the head-twitch response (HTR) in mice with a 5-HT2BR knockout, and 20 mg/kg of MDMA failed to increase the locomotor response in the same genotype compared to control mice, suggesting 5-HT2BR may play a significant role in the behavioral effects of psychedelics.

claimLSD and DOI promote neuritogenesis in cultured neurons derived from mice and Drosophila larvae.

measurementNeither LSD (0.5 mg/kg) nor DOI (8 mg/kg) increased cell proliferation in rats under chronic (7 days) or acute treatment regimens, as measured by the BrdU labelling technique.

claimDOI-induced long-term depression (LTD) in cortical neurons involves the internalization of AMPA receptors, which affects synaptic strength.

claimThe neural plasticity effects of DOI and 25I-NBOMe are primarily mediated through serotonin receptors, specifically 5-HT2A and 5-HT2B.

claimHigh doses of DOI and 25I-NBOMe have been observed to reduce the proliferation and survival of new neurons, indicating potential risks associated with dosage.

claimIn ex vivo slices from P14-P21 mice, 1µM DOI induced Long-Term Depression (LTD) in mPFC layer 5 pyramidal neurons, reducing the amplitude of AMPA excitatory postsynaptic currents (EPSC) from layer 1 pyramidal stimuli by nearly half; this effect was mediated by 5-HT2AR and required the internalization of GluA2-containing AMPA receptors via Protein kinase C (PKC).

claimThe substances DOI and 25I-NBOMe influence neural plasticity by inducing transient dendritic remodeling and modulating synaptic transmission.

claimResearchers at the Northwestern University Feinberg School of Medicine reported that 1µM DOI transiently promoted dendritic remodeling in cultured cortical pyramidal neurons from rats, characterized by spine enlargement that began 30 minutes after exposure and returned to control size 60 minutes later, a process mediated by Kalirin-7.

claimThe substituted amphetamine 2,5-Dimethoxy-4-iodoamphetamine (DOI) is a psychedelic drug.

Construction of Knowledge Graphs: State and Challenges - arXiv arxiv.org arXiv 1 fact

procedureExternal knowledge bases can be queried to enhance knowledge graph data by using extracted global persistent identifiers (PID) such as ISBN numbers, DOIs, or ORCIDs to request information from Wikidata.

Associations between dietary diversity and self-rated health in a ... link.springer.com Springer Feb 28, 2025 1 fact

measurementThe article 'Associations between dietary diversity and self-rated health in a transverse study of four local food systems (French Guiana, Guadeloupe, Portugal and Senegal)' is identified by the DOI https://doi.org/10.1186/s12889-025-21872-8.

Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org Johns Hopkins Center for Psychedelic and Consciousness Research 1 fact

referenceTiwari, P., Davoudian, P. A., Kapri, D., Vuruputuri, R. M., and Karaba, L. published a study in Neuron in 2024 finding that ventral hippocampal parvalbumin interneurons gate the acute anxiolytic action of the serotonergic psychedelic DOI.

Hallucinogens | Springer Nature Link link.springer.com Springer 1 fact

referenceMarona-Lewicka D, Chemel BR, and Nichols DE (2008) found that the dopamine D(4) receptor is involved in the discriminative stimulus effects of LSD in rats, but not in the effects of the phenethylamine hallucinogen DOI.