Knowledge Tree
DNA methylation
Also known as: methylation
Facts (15)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 3 facts
claimForced expression of OSKM rejuvenates multiple cellular features of dermal fibroblasts from middle-aged donors, including the transcriptome, epigenomes (specifically histone and DNA methylation), and functional characteristics.
claimA single period of OSKM expression in naturally aged mice alters epigenetics, transcriptomes, and metabolomes, resulting in a younger configuration in various tissues and serum, including the reversal of DNA methylation and transcriptional changes and the restoration of aging-related serum metabolites and biomarkers to youthful levels.
claimThe removal of DNA methylation is a prerequisite for epigenetic rejuvenation and the generation of induced pluripotent stem cells (iPSCs).
A Hilbertian approach to biological problems | PLOS Complex ... journals.plos.org Nov 5, 2024 3 facts
claimIntrinsic membrane excitability can be altered through dynamic epigenetic modification of DNA, specifically through methylation, which controls the expression of ion channels and synaptic response.
referenceJ.P. Meadows, M.C. Guzman-Karlsson, S. Phillips, J.A. Brown, S.K. Strange, J.D. Sweatt, et al. published 'Dynamic DNA methylation regulates neuronal intrinsic membrane excitability' in Science Signaling in 2016.
referenceJ.P. Meadows, M.C. Guzman-Karlsson, S. Phillips, C. Holleman, J.L. Posey, J.J. Day, et al. published 'DNA methylation regulates neuronal glutamatergic synaptic scaling' in Science Signaling in 2015.
Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Apr 16, 2018 2 facts
claimAlpha-ketoglutarate (aKG) enters the nucleus to serve as a substrate for ten-eleven translocation (TET) proteins for DNA methylation and for Jumonji C domain demethylase (JHDMs) for histone demethylation.
claimAlpha-ketoglutarate (aKG)-dependent DNA and histone methylation may promote naïve pluripotency.
Industry-Based Misconceptions Regarding Cross-Pollination of ... frontiersin.org Jan 25, 2022 1 fact
claimEpigenetics, characterized by histone modifications and DNA methylation, can alter the expression of stress-responsive genes and influence cannabinoid production in plants.
The Problem of Hard and Easy Problems cambridge.org Mar 31, 2023 1 fact
claimDavid Chalmers' 'gene*' concept encompasses a wide range of biological and environmental factors, including chromosomes, plasmids, maternal RNA, transcription factors, DNA methylation, histone acetylation, mitochondria, and various environmental influences like drugs, pathogens, viruses, and prions.
Editorial: Inflammation and chronic disease - Frontiers frontiersin.org Jul 1, 2024 1 fact
claimSocial and physical environments during early development are predictive of DNA methylation of inflammatory genes in young adulthood, according to a 2017 study by McDade et al.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 1 fact
claimThe Nrf2 pathway encompasses epigenetic modifications, including DNA methylation and alterations in histone acetylation, which sustain prolonged expression of antioxidant genes.
Integrating allostasis and emerging technologies to study complex ... nature.com Nov 5, 2025 1 fact
claimMulti-layered models that integrate DNA methylation, RNA-seq, proteomic, and metabolomic data have demonstrated high accuracy in predicting both infection status and severity levels.
The New Field of Network Physiology: Building the Human ... frontiersin.org 1 fact
claimGestational obesity induces DNA methylation reorganization of skeletal muscle-specific genes, as reported in a 2020 study by Prats-Puig et al. published in Frontiers in Physiology.
Research reveals devastating impact of Western diet on human health news-medical.net Jun 18, 2023 1 fact
claimThe Western diet alters epigenetics and gene expression through mechanisms including changes in nutrient availability, hormonal levels, the supply of cofactors for gene expression, transcription factors, cellular signaling pathways, and deoxyribonucleic acid (DNA) methylation, as well as inter- and transgenerational effects.