Knowledge Tree
DNA damage response
Also known as: DDR, DNA damage response machinery, DNA damage pathways, DNA repair response, DNA damage responses
Facts (6)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 3 facts
referenceDNA damage responses and p53 are involved in the aging process, as reviewed by Ou and Schumacher in a 2018 article in Blood.
claimIn telomere-dysfunctional animals, administration of nicotinamide mononucleotide (NMN) preserves telomere length, inhibits the DNA damage response and p53, enhances mitochondrial activity, and reverses liver fibrosis.
claimThe DNA repair response in stem cells declines with ageing, leading to the loss of stem cell properties, DNA damage-caused cellular senescence, and organ atrophy.
Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org 1 fact
claimIncreased cholesterol synthesis in hematopoietic stem cells confers enhanced myeloablative effects of chemotherapy and abrogates the DNA damage response upon the induction of systemic inflammation.
Chronic inflammation in the etiology of disease across the life span nature.com Dec 5, 2019 1 fact
claimPartial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans, as reported in a 2016 study in Brain, Behavior, and Immunity.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 1 fact
claimPost-translational modification of the RNA m6A demethylase ALKBH5 regulates the reactive oxygen species (ROS)-induced DNA damage response.