Knowledge Tree
dendritic cells
Facts (47)
Sources
The components of the immune system - Immunobiology - NCBI - NIH ncbi.nlm.nih.gov 13 facts
claimDendritic cells are specialized to take up antigens and display them for recognition by lymphocytes.
claimUpon encountering a pathogen, immature dendritic cells rapidly mature and migrate to lymph nodes.
claimThe myeloid progenitor cell is the precursor for granulocytes, macrophages, dendritic cells, and mast cells of the immune system.
claimAntigen is carried from sites of infection to peripheral lymphoid organs primarily within macrophages and dendritic cells.
claimWithin lymphoid organs, specialized cells such as mature dendritic cells display antigen to lymphocytes.
claimLymphocytes continually recirculate through peripheral lymphoid tissues, where they encounter antigens carried from infection sites primarily within macrophages and dendritic cells.
claimDendritic cells enter tissues as immature phagocytes to ingest antigens and subsequently migrate into lymphoid tissue as antigen-presenting cells.
claimImmature dendritic cells migrate from the blood to reside in tissues, where they are phagocytic and macropinocytic, ingesting large amounts of extracellular fluid.
claimThe myeloid progenitor is the precursor cell type for granulocytes, macrophages, dendritic cells, and mast cells of the immune system.
procedureDuring a peripheral infection, dendritic cells take up large amounts of antigen and travel through afferent lymphatic vessels into draining lymph nodes to display the antigen to and activate recirculating T lymphocytes.
claimWithin lymphoid organs, specialized cells such as mature dendritic cells display antigens to lymphocytes.
claimDendritic cells are specialized to take up antigen and display it for recognition by lymphocytes.
claimUpon encountering a pathogen, dendritic cells rapidly mature and migrate to lymph nodes.
Parts of the Immune System | Children's Hospital of Philadelphia chop.edu 11 facts
claimDendritic cells are the most common and powerful type of antigen-presenting cell.
procedureDendritic cells, macrophages, and B cells must travel to the draining lymph node to activate the adaptive immune response when acting as antigen-presenting cells.
procedureDendritic cells migrate to the nearest lymph node to present antigens to help activate T cells.
claimDendritic cells act as a bridge between the innate and adaptive immune responses.
claimUnlike neutrophils, macrophages, and dendritic cells, which use phagocytosis, natural killer (NK) cells attach to infected cells and release chemicals into them to kill them.
claimDendritic cells can process and present most types of pathogens, including viruses, bacteria, fungi, and parasites.
claimThe primary purpose of dendritic cells is to bridge the innate and adaptive immune responses.
claimDendritic cells are characterized by long tentacles and use phagocytosis to trap pathogens in tissues.
claimDendritic cells, macrophages, and B cells are the three cell types that can serve as antigen-presenting cells (APCs).
claimWhen dendritic cells encounter a pathogen, they phagocytose the pathogen, break it into pieces, and display those pieces on their surface as signals to other immune system components.
procedureDendritic cells are produced in bone marrow, migrate through the blood to tissues to monitor for pathogens, and upon encountering a pathogen, phagocytose it and present pieces of it as antigens on their surface.
3. The Innate Immune System - Immunopaedia immunopaedia.org.za 7 facts
claimDendritic cells utilize pinocytosis (the uptake of small droplets of liquids in vesicles) and phagocytosis to uptake foreign proteins and infectious agents.
claimDendritic cells circulate in the blood before migrating to epithelial sites of skin and mucosal tissues, where they remain as immature cells.
claimDendritic cells are migratory, sparsely distributed cells specialized for sampling infectious agent entry sites.
claimDendritic cells are categorized into two common subsets: plasmacytoid dendritic cells (pDCs), which are derived from lymphoid precursors, and myeloid dendritic cells (mDCs), which are derived from myeloid precursors.
claimDendritic cells function as elements of the innate immune system and as antigen-presenting cells for T cell activation, effectively linking innate and adaptive immune responses.
claimDuring emigration to secondary lymphoid organs, dendritic cells process captured molecules into small peptides, link them to MHC-II molecules, express them on the cell surface, and present antigens to naive and memory T cells.
claimThe uptake of foreign proteins and infectious agents results in the activation of dendritic cells, which promotes maturation, the expression of the chemokine receptor CCR7, and migration from the periphery to secondary lymphoid organs.
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 7 facts
claimActivated macrophages, dendritic cells, other immune cells, and endothelial cells release pro-inflammatory cytokines.
claimThe release of IFN-γ or TNF-α during a cytokine storm leads to the activation of macrophages, dendritic cells, other immune cells, and endothelial cells.
claimChemokines regulate the movement and localization of lymphocytes and a subset of dendritic cells.
claimPro-inflammatory cytokines are secreted by Th1 cells, CD4+ cells, macrophages, and dendritic cells.
procedureIn the pathogenesis of a cytokine storm, the activation of T cells or the lysis of immune cells induces the release of IFN-γ or TNF-α, which subsequently activates macrophages, dendritic cells, other immune cells, and endothelial cells.
referenceIL-18 is classified as a pro-inflammatory cytokine, is produced by macrophages, dendritic cells, and epithelial cells, binds to the CD218a (IL-18Ra) receptor, targets monocytes and T cells, and functions in recruiting monocytes and T lymphocytes, synergizing with IL-12 to induce IFN-gamma production, and inhibiting angiogenesis.
referenceIL-1 is classified as a pro-inflammatory cytokine, is produced by macrophages, B cells, and dendritic cells, binds to the CD121a receptor, targets B cells, NK cells, and T cells, and functions in pyrogenic activity, inflammation, cell proliferation, differentiation, and bone marrow cell proliferation.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 5 facts
claimLeptin promotes the phagocytic function of immune cells, stimulates pro-inflammatory cytokine production, and regulates the functions of neutrophils, natural killer (NK) cells, and dendritic cells.
claim1,25-dihydroxyvitamin D3 modulates the functional phenotype of helper T cells and dendritic cells.
referenceDendritic cells from human tissues express receptors for the immunoregulatory vitamin D3 metabolite, dihydroxycholecalciferol, as reported in a 1987 study in Immunology.
claimThe vitamin D receptor (VDR) is expressed in several types of immune cells, including monocytes, macrophages, dendritic cells, and activated T cells.
claimProbiotics modulate immune functions by interacting with receptors on intestinal epithelial cells, dendritic cells, and M-cells.
How the Immune System Works with Primary Immunodeficiency igcares.com 1 fact
claimDendritic cells are important for presenting antigens to immune system cells.
The Role of Immune Cells in Inflammation jmolpat.com 1 fact
claimInnate immune cells, specifically macrophages, dendritic cells, and neutrophils, initiate the pathophysiological processes of inflammation by using Pattern Recognition Receptors (PRRs) to recognize harmful stimuli.
What are Cytokines? Types & Function - Cleveland Clinic my.clevelandclinic.org Jan 3, 2023 1 fact
claimImmune cells that release cytokines include macrophages, dendritic cells, lymphocytes (T and B lymphocytes), monocytes, neutrophils, basophils, eosinophils, and mast cells.
Overview of the Immune System - Merck Manuals merckmanuals.com 1 fact
claimThe category of white blood cells known as phagocytes includes macrophages, neutrophils, monocytes, and dendritic cells.