Knowledge Tree
cocaine
Facts (11)
Sources
“Plants of the Gods” and their hallucinogenic powers in ... surgicalneurologyint.com Jul 19, 2021 3 facts
claimCocaine acts as an indirect sympathomimetic drug that crosses the blood–brain barrier and blocks the transport of dopamine, serotonin, and norepinephrine, which inhibits the re-uptake of these neurotransmitters at presynaptic terminals and increases their quantity and receptor activation in postsynaptic neurons.
perspectiveThe book Plants of the Gods: Their Sacred, Healing, and Hallucinogenic Powers provides a brief description of narcotics and cocaine, which may be because narcotics produce euphoria but are generally not hallucinogenic.
claimCocaine is a tropane alkaloid extracted from the leaves of two coca species of plants (Erythroxylaceae coca).
Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Dec 19, 2024 2 facts
accountA human-controlled trial at the New York State Psychiatric Institute found that ketamine administered to cocaine-addicted patients who were not seeking treatment or abstinence reduced their cocaine self-consumption and resulted in high scores on the Hood Mysticism Scale (HMS) compared to the Clinician-Administered Dissociative States Scale (CADSS) and the Near-Death Experience Scale (NDES).
referenceMoulin and Schiöth (2020) published a study in Behavioral and Brain Functions analyzing the homeostatic dynamics of ionotropic glutamatergic receptors in the ventral tegmental area (VTA) following cocaine exposure, focusing on excitability, synaptic balance, and addiction.
Substance Abuse and Evolution (Chapter 12) - Evolutionary Psychiatry cambridge.org Sep 8, 2022 2 facts
referenceK. S. Kendler, J. Myers, and C. A. Prescott authored the 2007 article 'Specificity of genetic and environmental risk factors for symptoms of cannabis, cocaine, alcohol, caffeine, and nicotine dependence' published in Archives of General Psychiatry.
referenceF. J. Muñoz-Cuevas, J. Athilingam, D. Piscopo, and Linda Wilbrecht demonstrated that cocaine-induced structural plasticity in the frontal cortex correlates with conditioned place preference in a 2013 study published in Nature Neuroscience.
Ancient Roots of Today's Emerging Renaissance in ... link.springer.com 1 fact
claimArtifacts found in a 1,000-year-old ritual bundle from the pre-Inca Tiwanaku civilization contained traces of benzoylecgonine (a cocaine metabolite), bufotenine (an alkaloid in psychedelic snuff), psilocin (the active agent in magic mushrooms), and harmine and dimethyltryptamine (active ingredients in ayahuasca).
What Western medicine can learn from the ancient history of ... - BBC bbc.com Sep 11, 2024 1 fact
accountThe shaman's bag discovered in Bolivia contained a snuffing tube, spatulas for crushing psychoactive seeds, and chemical traces of cocaine, psilocin (an active hallucinogen in magic mushrooms), and the base ingredients of the psychoactive tea ayahuasca.
Medical Hallucination in Foundation Models and Their Impact on ... medrxiv.org Nov 2, 2025 1 fact
claimThe LLM's generated chronological ordering of clinical events was generally correct but missed several important landmark events of the patient, such as specific history of oxycodone and cocaine use in a case of opioid use disorder.
Overview of Anxiety Disorders - Psychiatry - MSD Manuals msdmanuals.com 1 fact
claimSubstances and illicit drugs including caffeine, cocaine, and MDMA (ecstasy) can directly induce anxiety.