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chronic kidney disease
Also known as: chronic renal failure, chronic renal disease, Chronic kidney disease, chronic kidney disease, CKD, chronic kidney diseases
Facts (22)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 8 facts
claimPhase I clinical trials testing the efficacy and safety of mesenchymal stem cells in chronic kidney disease treatment include trials using autologous bone marrow MSCs (NCT02166489 and NCT02195323) and adipose-derived MSCs (NCT02266394 and NCT01840540).
measurementA clinical trial (NCT02848131) suggested that senolytics using a combination of Dasatinib and Quercetin (D + Q) improved physical function in patients with chronic kidney disease (CKD).
claimChronic kidney disease (CKD) is characterized by persistent kidney function decline and often progresses to end-stage renal disease (ESRD).
claimMesenchymal stem cell (MSC) transplantation is explored as a therapeutic method to slow or reverse chronic kidney disease progression due to the cells' easy collection, low immunogenicity, and high paracrine potential.
claimBone marrow-derived mesenchymal stem cells and adipose-derived mesenchymal stem cells demonstrate renoprotective effects in chronic kidney disease, specifically by decreasing fibrosis, glomerulosclerosis, and intrarenal inflammatory infiltrate.
claimClinical trials employing mesenchymal stem cells to treat chronic kidney disease face challenges including determining the optimal administration method, ensuring cell flourishing, tracking injected cells, preventing immunological rejection, improving homing and engraftment, and increasing immune acceptance.
claimCellular senescence, stress-induced premature ageing, the senescence-associated secretory phenotype (SASP), oxidative stress, and inflammation contribute to the development of chronic kidney disease (CKD).
claimDrugs targeting senescence-associated secretory phenotype (SASP), such as glucocorticoids, resveratrol, and protease inhibitors, attenuate chronic kidney disease (CKD) primarily by inhibiting NF-κB signals and reducing reactive oxygen species (ROS).
Short- and long-term health consequences of sleep disruption dovepress.com May 19, 2017 4 facts
referenceDavis et al. (2012) studied the prevalence of sleep disturbances in children and adolescents with chronic kidney disease.
measurementIn a study of 159 children and adolescents with chronic kidney disease, 58.5% exhibited symptoms of sleep disturbance as measured by the Epworth Sleepiness Scale.
referenceBarmar et al. (2009) compared sleep/wake behavior in chronic kidney disease (CKD) stages 4 to 5 and hemodialysis populations using wrist actigraphy.
claimAmong children and adolescents with chronic kidney disease, sleep disturbance is most frequent in the dialysis group compared to pre-dialysis and transplant groups.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 3 facts
claimChronic kidney disease (CKD) is characterized by low-grade inflammation, which leads to the retention of pro-inflammatory molecules in the blood and contributes to disease progression and mortality.
claimChronic inflammation is associated with multiple diseases, including cardiovascular disease, diabetes, malignancy, autoimmune disease, and chronic hepatic and renal disease.
claimLow-grade inflammation is a common feature of chronic kidney disease (CKD) that contributes to disease progression and mortality by leading to the retention of pro-inflammatory molecules in the blood.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 2 facts
claimTelomere attrition is associated with chronic kidney diseases.
referenceGlassock, R.J. and Rule, A.D. published a study in 2016 in the journal Nephron titled 'Aging and the kidneys: anatomy, physiology and consequences for defining chronic kidney disease', which discusses the anatomy, physiology, and consequences of aging kidneys for defining chronic kidney disease.
Editorial: Inflammation and chronic disease - Frontiers frontiersin.org Jul 1, 2024 2 facts
claimInflammation is associated with the morbidity and mortality of cardiovascular disease, chronic kidney disease, diabetes mellitus, non-alcoholic fatty liver disease, cancer, autoimmune diseases, neurodegenerative disorders, and behavioral health disorders.
referenceElevated systemic immune inflammation levels increase the risk of total and cause-specific mortality among patients with chronic kidney disease, according to a 2023 multi-center longitudinal study published in Inflammation Research.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 1 fact
claimProtein-energy malnutrition (PEM) in the developed world commonly occurs secondary to chronic diseases that interfere with nutrient metabolism, such as inflammatory bowel disease, chronic renal failure, or cancer.
Chronic inflammation in the etiology of disease across the life span nature.com Dec 5, 2019 1 fact
claimSystemic chronic inflammation (SCI) leads to several diseases that represent the leading causes of disability and mortality worldwide, including cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease, and autoimmune and neurodegenerative disorders.
Acute v chronic inflammation in the body: what's the difference? cbhs.com.au Mar 20, 2020 1 fact
claimResearch suggests a link between chronic inflammation and chronic diseases, including cardiovascular disease, chronic kidney disease, and type 2 diabetes.