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CD4+ T cells
Also known as: CD4 T cells, CD4+ cells, CD4+ T-cells, CD4+ T cells
Facts (10)
Sources
Integrating allostasis and emerging technologies to study complex ... nature.com Nov 5, 2025 3 facts
claimChronic unpredictable stress (CUS), including factors such as sporadic light exposure and food or water deprivation, drives the differentiation of naïve CD4+ and CD8+ T-cells toward pro-inflammatory phenotypes.
claimAcute phase HIV infection triggers immune activation, evidenced by the proliferation of CD4+ T-cells and elevated levels of inflammatory biomarkers such as IL-6, D-dimer, and CRP.
claimClinical studies link chronic psychosocial stress to systemic inflammation and immune imbalance, evidenced by elevated CD4+ and CD8+ T-cell subset population frequencies and increased IL-6 levels in chronically stressed individuals.
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 3 facts
claimIL-1β stimulates CD4+ cells and differentiates them into Th17 cells.
claimPro-inflammatory cytokines are secreted by Th1 cells, CD4+ cells, macrophages, and dendritic cells.
claimRegulatory T cells (Treg), defined as CD4+, CD25+, and Foxp3+ cells, are recruited to sites of infection to mediate immune regulation and control cellular immune responses to viral infections.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 2 facts
referenceBoonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF, and O'Garra A published '1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells' in The Journal of Immunology in 2001 (volume 167, issue 9, pages 4974-4980), reporting that 1alpha,25-dihydroxyvitamin D3 directly enhances Th2 cell development from naive CD4(+) T cells.
claimT cells expressing the cell-surface protein CD4 are divided into two subsets: T helper (Th)1 cells, which are primarily involved in activating macrophages and inflammatory responses, and Th2 cells, which are primarily involved in stimulating antibody production by B cells.
3. The Innate Immune System - Immunopaedia immunopaedia.org.za 1 fact
claimMucosa-associated invariant T (MAIT) cells express a semi-invariant T-cell receptor (TCR) containing the Vα7.2-Jp33 chain, are double negative for CD4 and CD8, and recognize hydrophilic antigens presented in MR1 (MHC-I-related) molecules present in B cells.
The immune system and primary immunodeficiency primaryimmune.org 1 fact
claimT cells are categorized into killer (cytotoxic) T cells (CD8 T cells), helper T cells (CD4 T cells), and regulatory T cells, each with distinct roles in the immune system.