Knowledge Tree
Cataplexy
Facts (24)
Sources
Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov 23 facts
claimPharmacological treatment for daytime sleepiness in narcolepsy with cataplexy involves modafinil or amphetamine-like stimulants, which likely function by increasing dopamine transmission.
claimNarcolepsy is associated with symptoms including excessive daytime sleepiness, cataplexy, sleep paralysis, hypnagogic/hypnopompic hallucinations, insomnia, autonomic behavior, and REM behavior disorder.
claimThe loss of hypocretin cells in narcolepsy with cataplexy may be autoimmune in nature due to the association with the HLA-DQB1*0602 haplotype.
claimTricyclic antidepressants or serotonin and norepinephrine reuptake inhibitors are typically used to treat cataplexy and abnormal REM sleep symptoms, such as sleep paralysis and hallucinations, with adrenergic reuptake inhibition believed to be the primary mode of action.
measurementApproximately 3.9 percent of the general population has Multiple Sleep Latency Test (MSLT) score abnormalities consistent with narcolepsy without cataplexy.
measurementThe prevalence of narcolepsy with definite cataplexy in adults is 0.02 to 0.05 percent of the population in Western Europe and North America.
claimAnti-Ma-2 antibodies in cancer patients tend to cause hypothalamic lesions, which may precipitate daytime sleepiness and cataplexy, according to Rosenfeld et al. (2001).
claimAnti-Ma-2 antibodies can cause hypothalamic lesions, which may precipitate daytime sleepiness and cataplexy.
claimCataplexy and abnormal REM sleep symptoms, such as sleep paralysis and hallucinations, are typically treated with tricyclic antidepressants or serotonin and norepinephrine reuptake inhibitors, with adrenergic reuptake inhibition believed to be the primary mode of action.
referenceKanbayashi et al. (2002) measured cerebrospinal fluid hypocretin-1 (orexin-A) concentrations in patients with narcolepsy (with and without cataplexy) and idiopathic hypersomnia.
claimNarcolepsy with cataplexy affects males and females equally, with symptoms usually arising during adolescence.
claimTricyclic antidepressants or serotonin and norepinephrine reuptake inhibitors are typically used to treat cataplexy and abnormal REM sleep symptoms, such as sleep paralysis and hallucinations, with adrenergic reuptake inhibition believed to be the primary mode of action.
claimIndividuals with narcolepsy with cataplexy experience severe neuronal loss in brain regions responsible for regulating the sleep-wake cycle, specifically losing approximately 70,000 hypothalamic neurons that produce the neuropeptide hypocretin (orexin).
claimSusceptibility to narcolepsy with cataplexy is influenced by both genetic and environmental factors.
claimThe treatment of narcolepsy without cataplexy and idiopathic hypersomnia utilizes compounds similar to those used for narcolepsy with cataplexy, most notably modafinil and amphetamine-like stimulants (Billiard and Dauvilliers, 2001).
referenceKrahn et al. (2002) analyzed hypocretin (orexin) levels in the cerebrospinal fluid of patients with narcolepsy and their relationship to cataplexy and HLA DQB1*0602 status.
referenceAnic-Labat S, Guilleminault C, Kraemer HC, Meehan J, Arrigoni J, and Mignot E validated a cataplexy questionnaire in a study of 983 sleep-disorders patients, published in Sleep in 1999.
claimNarcolepsy with cataplexy affects males and females equally.
claimTricyclic antidepressants or serotonin and norepinephrine reuptake inhibitors are typically used to treat cataplexy and abnormal REM sleep symptoms, such as sleep paralysis and hallucinations, with adrenergic reuptake inhibition believed to be the primary mode of action.
claimTreatment of the underlying cancer may reverse symptoms of excessive sleepiness and cataplexy in some patients.
claimIndividuals who suffer from narcolepsy with cataplexy typically carry the haplotype HLA-DQB1*0602 and experience severe neuronal loss in brain regions responsible for regulating the sleep-wake cycle.
claimSodium oxybate (gamma hydroxybutyric acid) is used at night to consolidate disturbed nocturnal sleep and is effective in treating cataplexy and other narcolepsy symptoms.
claimCataplexy is defined as sudden and brief bilateral episodes of muscle weakness triggered by a strong emotional stimulus, such as laughing.
Physiology, Sleep Stages - StatPearls - NCBI Bookshelf - NIH ncbi.nlm.nih.gov 1 fact
claimNarcolepsy is a sleep cycle disorder characterized by persistent daytime sleepiness and brief episodes of muscle weakness known as cataplexy.