Knowledge Tree
autophagy
Facts (30)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 13 facts
referenceAutophagy plays a significant role in neurons, as reviewed by Stavoe and Holzbaur in the Annual Review of Cell and Developmental Biology (2019).
claimStrategies for restoring a youthful skin state include using stem cells and related extracellular vesicles (EVs), pharmacological activation of autophagy, maintaining circadian rhythmicity in skin-resident stem cells, and regulating metabolic homeostasis to restore mitochondrial integrity and metabolic output.
referenceAutophagy and the lysosomal degradative system play a central role in aging, according to Rajawat, Hilioti, and Bossis in their 2009 Ageing Research Reviews paper.
claimSenescent skin cells, senescence-associated secretory phenotype (SASP), oxidative stress, inflammation, and autophagy mediate the pathophysiology of skin ageing.
referenceAutophagy, lipophagy, and lysosomal lipid storage disorders are interconnected, as explored by Ward et al. in Biochimica et Biophysica Acta (2016).
claimTime-restricted feeding (TRF) drives a clock-dependent increase in autophagy activity to induce longevity extension.
referenceSirt1, a class III histone deacetylase, induces autophagy to prevent prion peptide neurotoxicity, according to Jeong et al. in Neurobiology of Aging (2013).
claimZhang, Z. Y. et al. identified autophagy as a regulatory mechanism of oxidative stress in age-related macular degeneration.
referenceReactive oxygen species (ROS) and autophagy interact through complex molecular regulatory mechanisms, as reported by Li et al. in Cellular and Molecular Neurobiology (2015).
claimMolecular pathways involving cellular senescence, oxidative stress, insulin signaling, autophagy, and inflammation are linked to the deterioration of cardiovascular homeostasis.
claimRapamycin improves the function of muscle stem cells (MuSCs) through the induction of autophagy in the Ercc1-/Δ progeria mouse model.
referenceAMPK-mediated pathways play a role in autophagy and aging, according to a 2022 review by Ge et al. in Biochimie.
claimEnhancing autophagy can resist oxidative damage and mitigate the progression of age-related macular degeneration (AMD).
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 11 facts
referenceAutophagy is a mechanism involved in kidney homeostasis and disease, according to Tang et al. in their 2020 review published in Nature Reviews Nephrology.
claimAutophagy functions at the intersection of aging, senescence, and cancer.
referenceLiu S, Yao S, Yang H, Liu S, and Wang Y authored 'Autophagy: Regulator of cell death', published in Cell Death & Disease in 2023 (14:648, doi: 10.1038/s41419-023-06154-8).
referenceSpermidine attenuates bleomycin-induced lung fibrosis in mice by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death, as found by Baek et al. in Experimental & Molecular Medicine (2020).
referenceKaushik S, Tasset I, Arias E, Pampliega O, Wong E, Martinez-Vicente M, et al. authored 'Autophagy and the hallmarks of aging', published in Ageing Research Reviews in 2021 (72:101468, doi: 10.1016/j.arr.2021.101468).
claimThe AMPK-mTOR-Ulk1/2 pathway regulates autophagy through cross-talk, shortcuts, and feedback mechanisms.
referenceThe induction of autophagy by spermidine promotes longevity, as demonstrated by Eisenberg et al. in Nature Cell Biology (2009).
referenceSpermidine induces autophagy and provides geroprotection through specific biological mechanisms, as detailed by Hofer et al. in Nature Aging (2022).
referenceKlionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, et al. authored 'Autophagy in major human diseases', published in The EMBO Journal in 2021 (40:e108863, doi: 10.15252/embj.2021108863).
referenceM.M. Mihaylova and R.J. Shaw published 'The AMPK signalling pathway coordinates cell growth, autophagy and metabolism' in Nature Cell Biology in 2011, describing how the AMPK pathway regulates cell growth, autophagy, and metabolism.
referenceGlick D, Barth S, and Macleod K authored 'Autophagy: cellular and molecular mechanisms', published in The Journal of Pathology in 2010 (221:3–12, doi: 10.1002/path.v221:1).
Medicinal plants: bioactive compounds, biological activities ... frontiersin.org 1 fact
referenceWang et al. (2024) published a study in Bioorganic Chemistry on novel GSH-responsive prodrugs derived from indole-chalcone and camptothecin that trigger apoptosis and autophagy in colon cancer.
Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Apr 16, 2018 1 fact
claimMitochondria influence cell death pathways, including necrosis, apoptosis, and autophagy, through the modulation of redox and calcium balance.
Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us 1 fact
claimSilybin induces autophagy in breast cancer via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3; it also prevents TPA and PMA induced MMP-9 expression and VEGF secretion via inactivation of the Raf/MEK/ERK pathway and blockade of AP-1 activation via MAPK signaling pathways, according to Wang et al. [101].
Targeting immunosenescence and inflammaging - Nature nature.com Sep 1, 2025 1 fact
referenceBharath et al. (2020) reported that metformin enhances autophagy and normalizes mitochondrial function to alleviate aging-associated inflammation.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 1 fact
claimCompounds such as baicalein, catechins, and nordihydroguaiaretic acid facilitate the removal of existing α-synuclein aggregates via augmented autophagy and proteasomal destruction.
Homeostatic medicine: a strategy for exploring health and disease link.springer.com Sep 26, 2022 1 fact
claimThe nitrate-sialin loop preserves radiation-lost salivary gland cells by regulating autophagy within those cells.