Knowledge Tree
autoimmune diseases
Facts (26)
Sources
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 10 facts
claimVitamin D is suggested to have utility in preventing and treating autoimmune diseases and graft rejections because Th2 cells and regulatory T cells are important regulators in these conditions.
referenceAntico A, Tampoia M, Tozzoli R, and Bizzaro N published 'Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature' in Autoimmunity Reviews in 2012 (volume 12, issue 2, pages 127-136), providing a systematic review on Vitamin D supplementation and autoimmune diseases.
claimVitamin D deficiency has been implicated in the development of autoimmune diseases, including insulin-dependent diabetes mellitus (IDDM), multiple sclerosis (MS), systemic lupus erythematosis (SLE), and rheumatoid arthritis (RA).
referenceAgmon-Levin N, Theodor E, Segal RM, and Shoenfeld Y published 'Vitamin D in systemic and organ-specific autoimmune diseases' in Clinical Reviews in Allergy & Immunology in 2013 (volume 45, issue 2, pages 256-266), discussing the role of Vitamin D in autoimmune diseases.
claimNatural age-related decline of immune function is associated with increased susceptibility to infections, poorer response to immunization, and higher risks of developing cancers and autoimmune diseases.
claimLower exposure to ultraviolet-B radiation and the associated decrease in endogenous vitamin D synthesis are hypothesized to play a role in the pathology of autoimmune diseases.
referenceCantorna MT and Mahon BD published a review in 2004 in Experimental Biology and Medicine presenting evidence for vitamin D as an environmental factor affecting the prevalence of autoimmune diseases.
claimThe clinical efficacy of vitamin D supplementation in the prevention and treatment of autoimmune diseases remains uncertain due to a lack of randomized controlled trials.
claimGenetic factors, such as VDR polymorphisms, and environmental factors, such as low UVB exposure and low dietary vitamin D intake, may contribute to low vitamin D status in autoimmune diseases.
claimAutoimmune diseases occur when the body mounts an immune response against its own tissue instead of a foreign pathogen.
The immune system and primary immunodeficiency primaryimmune.org 3 facts
claimIn some immunodeficiencies, the immune system is unable to discriminate between self and non-self, leading to autoimmune diseases where the immune system attacks the body's own cells or tissues.
claimMedications and conditions commonly associated with secondary immunodeficiencies include chemotherapy agents, immune suppressive medications, cancer, transplanted organ rejection, and autoimmune diseases.
claimIn some cases of primary immunodeficiency (PI), the immune system is unable to discriminate between self and non-self, leading to autoimmune diseases where the immune system attacks the body's own cells or tissues.
What are Cytokines? Types & Function - Cleveland Clinic my.clevelandclinic.org Jan 3, 2023 3 facts
claimExcessive cytokine release creates a heightened inflammatory response that can damage tissue and lead to conditions including autoimmune diseases, metabolic disorders, cancer, and sepsis.
claimIn autoimmune diseases, the body's immune cells mistakenly attack healthy cells.
claimExcessive levels of cytokines can lead to excess inflammation and conditions such as autoimmune diseases.
Inflammation: Types, symptoms, causes, and treatment medicalnewstoday.com 2 facts
claimChronic inflammation can persist for months or years and is associated with conditions such as diabetes, cardiovascular disease, and autoimmune diseases.
claimAutoimmune diseases, such as type 1 diabetes, occur when the body mistakenly perceives its own cells or tissues as harmful, triggering an inflammatory response.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 1 fact
claimPolyphenols from green tea and proanthocyanidins from grape seeds exhibit T-cell modulatory effects in models of autoimmune diseases by regulating transcription factors such as T-bet, GATA-3, and Foxp3.
Evolutionary Eating — What We Can Learn From Our Primitive Past todaysdietitian.com Apr 1, 2009 1 fact
claimAn increasing body of evidence suggests that diet acts as an environmental trigger for autoimmune diseases, such as type 1 diabetes, multiple sclerosis, rheumatoid arthritis, and psoriasis, in genetically susceptible individuals, with the dietary factors being foods introduced after the advent of agriculture.
The Center for Inflammation Science and Systems Medicine wertheim.scripps.ufl.edu 1 fact
claimPersistent inflammation increases the risk of developing autoimmune diseases, including metabolic syndrome, rheumatoid arthritis, diabetes, systemic lupus, inflammatory bowel disease, and asthma.
Modern Diet and its Impact on Human Health - Longdom Publishing longdom.org 1 fact
claimExcessive immunity, occurring when nutrition is abundant or redundant, can lead to inflammation, autoimmune diseases, and metabolic syndromes.
What is Inflammation? Causes, Effects, Treatment - Harvard Health health.harvard.edu Mar 27, 2023 1 fact
claimAutoimmune diseases, including type 1 diabetes, rheumatoid arthritis, lupus, psoriasis, inflammatory bowel disease, and multiple sclerosis, are known to cause chronic inflammation.
What Is Inflammation? Types, Causes & Treatment my.clevelandclinic.org Mar 22, 2024 1 fact
claimChronic inflammation is involved in the disease process of autoimmune diseases (lupus, rheumatoid arthritis, psoriasis, ankylosing spondylitis), cardiovascular diseases (heart disease, high blood pressure), certain cancers, gastrointestinal diseases (Crohn’s disease, inflammatory bowel disease), lung diseases (asthma, chronic obstructive pulmonary disease), mental health conditions (depression, anxiety), metabolic diseases (Type 2 diabetes), and neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease).
Inflammation: Definition, Diseases, Types, and Treatment - WebMD webmd.com Jul 14, 2024 1 fact
claimIn autoimmune diseases, the immune system triggers inflammation by mistakenly identifying regular body tissues as infected or unusual, leading to tissue damage.
What is the Impact of a Western Diet? - Robard Corporation robard.com 1 fact
claimThe Western diet is associated with the development of chronic conditions including diabetes, cardiovascular disease, inflammation, autoimmune diseases, and cancers.