Knowledge Tree
apoptosis
Facts (30)
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Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us 10 facts
claimEugenol, ursolic acid, linalool, and isoeugenol exhibit anti-neoplastic and anticancer properties by restricting cancer cell growth through apoptosis induction, cellular blockade, and inhibition of DNA synthesis, specifically demonstrating cytotoxic activity against Michigan Cancer Foundation-7 cells.
claimVitex Negundo modulates biological processes including apoptosis, cell cycle, sperm motility, polycystic ovary disease, and menstruation.
referenceSilymarin protects epidermal keratinocytes from ultraviolet radiation-induced apoptosis and DNA damage by utilizing the nucleotide excision repair mechanism, as reported by Katiyar, Mantena, and Meeran in 2011.
claimSilymarin inhibits growth and induces apoptosis in AGS human gastric cancer cells by modulating the MAPK signalling pathway, as reported by Kim SH et al. in 2019.
claimCarbazole alkaloids derived from Murraya koenigii trigger apoptosis and inhibit autophagic flux in human oral squamous cell carcinoma cells, according to a 2017 study by Utaipan et al.
claimTorres et al. (2018) found that Ocimum basilicum, but not Ocimum gratissimum, presents cytotoxic effects on the human breast cancer cell line MCF-7, inducing apoptosis and triggering the mTOR/Akt/p70S6K pathway.
claimSilymarin prevents apoptosis partially through inhibition of the caspase-8 pathway, according to Rajnochova Svobodova et al. [108].
claimSilybin-induced apoptosis in human hepatocarcinoma cells occurs in parallel with increased ceramide synthesis and miRNA secretion, as reported by Zappavigna S et al. in 2019.
claimFlavonoid-rich extract of Murraya koenigii alleviates in-vitro LDL oxidation and oxidized LDL-induced apoptosis in raw 264.7 Murine macrophage cells.
claimSilymarin inhibits gastric cancer growth and apoptosis through modulation of the MAPK signaling pathway, according to Kim et al. [97].
3. The Innate Immune System - Immunopaedia immunopaedia.org.za 4 facts
procedurePerforin induces apoptosis in target cells by forming pores in the target cell membrane, allowing granzymes and associated molecules to enter the cell.
claimWhen a target cell exhibits decreased expression of MHC-I, the inhibitory signal from the Natural Killer (NK) cell's killer inhibitory receptors (KIRs) decreases, shifting the signal balance toward activation and initiating apoptosis.
claimNatural Killer (NK) cells contribute to the innate immune response by nonspecifically eliminating target cells, such as virus-infected or malignant cells, through apoptosis independently of T or B cells.
procedureOnce the signal balance shifts toward activation, Natural Killer (NK) cells initiate a killing mechanism by releasing intracellular granules containing perforin and granzymes to induce apoptosis in target cells.
The Role of Immune Cells in Inflammation jmolpat.com 3 facts
claimThe article 'Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis' is distributed under the Creative Commons Attribution Non Commercial Share Alike 4.0 license.
claimOxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis, according to the 2012 study by Shimada K et al. published in Immunity.
referenceThe scientific paper titled 'Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis' was authored by Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, et al., and published in the journal Immunity in 2012.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... academia.edu 3 facts
referenceDing and Fisher (2002) discussed the induction of apoptosis in cancer cells as a new therapeutic opportunity.
claimMolecular targeting therapy is a therapeutic approach for cancer that focuses on inducing apoptosis, as discussed by Hassan et al. (2014).
referencePieme et al. (2014) reported that Annona muricata (Annonaceae) extract exhibits antiproliferative activity and induces apoptosis in human cancer cells, published in BMC Complementary and Alternative Medicine.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 2 facts
claimPlant-derived secondary metabolites have anticancer potential by addressing cancer characteristics such as continuous proliferation, evasion of apoptosis, angiogenesis, and metastatic ability.
claimPolyphenolic compounds, specifically resveratrol and EGCG, induce apoptosis in cancer cells by depolarizing the mitochondrial membrane and releasing cytochrome c.
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 2 facts
claimCells undergoing apoptosis release pathogen-associated molecular patterns (PAMPs) that bind to pattern recognition receptors (PRRs), leading to the activation of TLR2, TLR3, or TLR4.
claimIn the context of SARS-CoV-2 infection, the cytokines IL-12 and IL-8 enhance IFN-γ production, which attracts monocytes and T lymphocytes, but not neutrophils, to induce apoptosis and eliminate infected cells.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 2 facts
The Four Stages of Wound Healing woundevolution.com 1 fact
claimThe maturation phase of wound healing features a stabilization of vascularity from the previous stages and involves apoptosis, or programmed cell annihilation, of cells and molecules found in those stages.
Vernonia amygdalina: a comprehensive review of the ... frontiersin.org 1 fact
referenceNarayanan B. A., Geoffroy O., Willingham M. C., Re G. G., and Nixon D. W. (1999) investigated p53/p21 (WAF1/CIP1) expression and its role in G1 arrest and apoptosis in cancer cells treated with ellagic acid.
Medicinal plants: bioactive compounds, biological activities ... frontiersin.org 1 fact
referenceWang et al. (2024) published a study in Bioorganic Chemistry on novel GSH-responsive prodrugs derived from indole-chalcone and camptothecin that trigger apoptosis and autophagy in colon cancer.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... ouci.dntb.gov.ua 1 fact
claimDing, H. & Fisher, D. E. (2002) identified new therapeutic opportunities for inducing apoptosis in cancer cells.