Knowledge Tree
antimicrobial resistance
Also known as: AMR
Facts (16)
Sources
Medicinal plants: bioactive compounds, biological activities ... frontiersin.org 11 facts
claimTwo factors cause antimicrobial resistance (AMR) in bacteria with high inoculum sizes: (i) a reduction in drug concentration due to the presence of supplementary drug target sites in both viable and non-viable cells, and (ii) an inadequate ratio of medicinal compounds to the high concentration of microorganisms.
claimAntimicrobial resistance (AMR) is a natural phenomenon where microorganisms, including bacteria, fungi, and protozoa, acquire the ability to survive and proliferate despite the administration of antibacterial, antifungal, and antiprotozoal medications.
claimThe World Health Organization (WHO) has designated antimicrobial resistance (AMR) as a significant global health challenge due to the emergence of superbugs resistant to many medications.
claimQuave (2016) posits that traditional medicine is a valuable source for discovering new solutions to combat antimicrobial resistance, specifically regarding antibiotics derived from nature.
claimSpontaneous mutations, which cause antimicrobial resistance, occur in actively dividing cells as random replication mistakes or improper DNA damage repair.
referenceChandra et al. published a review titled 'Antimicrobial resistance and the alternative resources with special emphasis on plant-based antimicrobials' in the journal Plants in 2017.
referenceDilbato, Begna, and Joshi (2019) reviewed the challenges, opportunities, and future prospects of using medicinal plants as alternative solutions to combat antimicrobial resistance.
referenceSari et al. (2023) published a review in the Indonesian Journal of Pharmacy regarding the mechanism of antimicrobial resistance and the potential of red ginger as a source of natural antioxidants.
referenceda Silva et al. (2024) explored whether phenolics can mitigate antimicrobial resistance in foodborne pathogens in an article for Current Opinion in Food Science.
measurementAntimicrobial resistance currently accounts for millions of fatalities annually, with forecasts indicating a rise to 10 million deaths per year by 2050.
claimPlant-derived chemicals, particularly those from the Caucasus region, address antimicrobial resistance through methods including membrane rupture, interference with biosynthesis and metabolism, biofilm inhibition, and reactive oxygen species formation.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... ouci.dntb.gov.ua 2 facts
referenceGuedes, B. N. et al. (2024) published 'Natural antibiotics against antimicrobial resistance: sources and bioinspired delivery systems' in the Brazilian Journal of Microbiology, which explores natural sources of antibiotics and delivery systems to combat antimicrobial resistance.
referenceM. B. Sannathimmappa (2025) published an update on antibiotic stewardship, challenges, and future directions for combating antimicrobial resistance in Clinical Medical Reviews and Case Reports.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 1 fact
claimConcerns regarding antimicrobial resistance have increased interest in using plant-derived natural chemicals as substitutes for traditional antibiotics.
Tracking Inflammation Through Biomarkers rupahealth.com Jul 24, 2024 1 fact
claimUsing procalcitonin (PCT) levels to distinguish between bacterial and viral infections helps guide antibiotic use and reduce unnecessary prescriptions that contribute to antimicrobial resistance.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... academia.edu 1 fact
claimNatural antibiotics are being investigated as a strategy to combat antimicrobial resistance, utilizing bioinspired delivery systems, as reported by Guedes et al. (2024).