concept

amyotrophic lateral sclerosis

Also known as: ALS

Facts (7)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 5 facts

claimClinical trials for treating amyotrophic lateral sclerosis with stem cells, such as NCT05306457, have been completed and yielded desired results using autologous mesenchymal stem cells, endogenous mesenchymal stem cell mobilization, neural stem cells, and T-cell vaccination combined with mesenchymal stem cell and neural stem cell therapy.

claimSenolytic therapy is rarely reported as a treatment for Parkinson’s disease and amyotrophic lateral sclerosis.

referenceLunn, J. S., Sakowski, S. A., and Feldman, E. L. reviewed stem cell therapies for amyotrophic lateral sclerosis, covering recent advances and future prospects.

claimiPSC-derived LewisX+CXCR4+beta1-integrin+ neural stem cells improve the amyotrophic lateral sclerosis phenotype by preserving motor neurons and muscle innervation in human and rodent models, according to Nizzardo et al. in Human Molecular Genetics (2016).

claimAlzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are classified as neurodegenerative diseases.

Rusty Gage, PhD - Salk Institute salk.edu Salk Institute 1 fact

referenceB.K. Kaspar, J. Lladó, N. Sherkat, J.D. Rothstein, and F.H. Gage demonstrated that retrograde viral delivery of IGF-1 prolongs survival in a mouse model of Amyotrophic Lateral Sclerosis (ALS).

Impact of sleep duration on executive function and brain structure nature.com Nature Mar 3, 2022 1 fact

procedureThe researchers excluded individuals from the study who had a history or current diagnosis of neurological disease, stroke, transient ischaemic attack, brain injury, subdural or subarachnoid haematoma, infection of the nervous system, brain abscess, haemorrhage, skull fracture, encephalitis, meningitis, chronic neurological problems, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, epilepsy, head injury, or alcohol, opioid, and other dependencies.