concept

allostatic load index

Also known as: allostatic load score

Facts (13)

Sources

Integrating allostasis and emerging technologies to study complex ... nature.com Nature Nov 5, 2025 12 facts

claimThe cumulative biological impact of chronic stress in cancer patients has been studied using the allostatic load index.

claimThe allostatic load index serves as a quantitative marker of chronic stress-related physiological adaptation and allostatic dysregulation.

claimThe allostatic load index, calculated by summing high-risk physiological biomarkers including systolic and diastolic blood pressure, BMI, fasting glucose, total cholesterol, HDL cholesterol, and CRP, was found to be elevated in black breast cancer survivors compared to black women without a cancer history.

claimThe allostatic load index is a tool used for quantifying stress-related physiological changes and identifying intermediate allostatic states.

claimIndividuals with schizophrenia exhibit significantly elevated allostatic load indices compared to age-matched controls, particularly in neuroendocrine and immune biomarkers.

claimPatients with depression show higher allostatic load indices compared to non-depressed controls, and cortisol levels in these patients positively correlate with the severity of depressive symptoms.

claimIn an elderly Puerto Rican cohort, an allostatic load index based on cardiovascular, metabolic, and inflammatory biomarkers showed no significant correlation with self-reported cancer status.

claimThe current allostatic load index is limited to biomarkers such as CRP, IL-6, and TNF-α, creating a need to incorporate additional biomarkers like activated T-cell subset frequencies and a broader range of cytokines to accurately capture immune allostatic load.

perspectiveThe utility of the allostatic load index in predicting cancer development and prognosis is controversial, with findings varying across populations, cancer types, and assessment methods.

claimThe allostatic load index has been proposed as a tool for evaluating the effectiveness of pharmacological and psychological interventions in patients with schizophrenia or bipolar disorder.

claimBlack breast cancer survivors exhibit an elevated allostatic load index compared to black women without a cancer history, suggesting a potential link between allostatic load and long-term prognosis in this population.

claimA study demonstrated the potential utility of the allostatic load index in predicting long-term health risks among breast cancer patients.

Explaining biological differences between men and women by ... link.springer.com Springer Mar 23, 2023 1 fact

claimThe study explored biomarkers representing four systems used to construct the allostatic load score: systolic blood pressure (cardiovascular), triglycerides, low density lipoprotein (LDL) cholesterol, and haemoglobin A1c (metabolic), C-reactive protein (inflammatory), and cortisol (neuroendocrine).