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Psilocybin may have been harnessed to increase adaptability and fitness through its capacity to modulate the 5-HT2A receptor-mediated active coping strategy, which provides elevated cortical plasticity, an enhanced rate of associative learning, and an elevated capacity to mediate psychological transformation, according to Carhart-Harris and Nutt (2017) and Brouwer and Carhart-Harris (2021).

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