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Vgontzas A.N., Bixler E.O., Lin H.M., Prolo P., Mastorakos G., Vela-Bueno A., Kales A., and Chrousos G.P. found that chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis, as published in the Journal of Clinical Endocrinology and Metabolism in 2001.

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