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Jerusalem et al. (2019) described bottom-up models of the nerve impulse as follows: “similar to the coupling of Nernst’s theory of the electrochemistry of semi-permeable membranes to the laws of electricity (e.g., Ohm’s and Coulomb’s laws) and Kelvin’s cable theory in the purely electrical HH model of the nerve impulse, aim primarily to itemize the different physics involved in the experimental observations linking them by physical laws.”

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