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The DSM-IV-TR diagnostic criteria for Panic Disorder With Agoraphobia (Code 300.21) require: (1) recurrent unexpected panic attacks, and (2) at least one attack followed by one month or more of persistent concern about additional attacks, worry about the implications or consequences of the attack (such as losing control or 'going crazy'), or a significant change in behavior related to the attacks. Additionally, the patient must exhibit the presence of Agoraphobia, and the panic attacks must not be due to the direct physiological effects of a substance (e.g., drug of abuse, medication) or a general medical condition (e.g., overactive thyroid).

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