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Psychoactive tryptamines act as potent 5-HT2A agonists and often demonstrate affinity for 5-HT1 and other 5-HT2 receptors, as well as potential interactions with ionotropic and metabotropic glutamate receptors, dopamine, acetylcholine, and trace amine-associated receptors (TAAR) (Carbonaro and Gatch 2016).

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