A non-integrative partial reprogramming protocol using a cocktail of mRNAs carrying OSKM + LIN28 alleviates cellular aging in naturally aged human fibroblasts and endothelial cells by resetting the epigenetic clock, reducing inflammatory responses in chondrocytes, and restoring youthful regenerative responses without altering cellular identity.

Authors

• Person: Not available Organization: Nature
  Cellular rejuvenation: molecular mechanisms and potential ... - Nature

Sources

• Cellular rejuvenation: molecular mechanisms and potential ... - Nature www.nature.com Nature via serper

Referenced by nodes (2)

• partial reprogramming concept
• OSKM concept