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The process of synaptic transmission involves the following steps: (1) the presynaptic membrane is depolarized by an action potential, (2) calcium voltage-gated channels open, (3) calcium flows into the terminal button, (4) membrane proteins in the presynaptic membrane change state, (5) neurotransmitters are released into the synaptic cleft via exocytosis, (6) neurotransmitters bind to receptors on the postsynaptic membrane, (7) ligand-gated ion channels on the postsynaptic membrane open or close, and (8) ions are redistributed in the postsynaptic cell, resulting in either excitatory or inhibitory responses.

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