The two-cell, two-gonadotropin hypothesis of estrogen synthesis in the human ovary states that androstenedione is produced in theca cells, transported to granulosa cells, aromatized to estrone, and finally converted to estradiol by 17-β-hydroxysteroid dehydrogenase type I.

Referenced by nodes (3)

• estradiol concept
• granulosa cells concept
• estrone concept