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Depression and sleep disturbance are linked as co-occurring symptoms of cytokine-based biotherapy [1] and are both elevated in populations experiencing high psychological distress [2]. Furthermore, sleep disturbance is clinically associated with depression in patients with Alzheimer’s disease [3], [4].
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Short- and long-term health consequences of sleep disruption dovepress.com 9 facts
referenceBoakye et al. (2016) reviewed neurobiological factors involved in the interactions between chronic pain, depression, and sleep disruption.
measurementIn a study of midlife women with a history of depression or anxiety, the odds ratios for the association between sleep disturbance and reduced HRQoL ranged from 2.04 to 2.96, with P < 0.05 across all domains.
claimA review by Meerlo et al. surveyed evidence indicating that disrupted sleep is a major causal factor in the development of depression.
claimPsychosocial outcomes such as depression, mood disturbances, risk-taking behavior, and academic performance are the primary factors affected by sleep disruption in adolescents.
claimIn adolescents, sleep disruption is associated with the new onset of poor mental health status, loneliness, worry, anxiety, and depression.
claimThe relationship between sleep disruption, life events (such as illness of a child), and increased stress responsivity is bidirectional, as anxiety and depression are associated with sleep disruption, making it challenging to separate cause from consequence.
claimThe reported frequency of sleep disturbance in adults is closely linked with the severity of self-reported symptoms of depression and anxiety.
claimIn a longitudinal, community-based study of midlife women with a history of depression or anxiety, sleep disturbance was significantly associated with reduced Health-Related Quality of Life (HRQoL) as measured by the 36-item Short Form Health Survey (SF-36).
claimThe high correlation between sleep disturbances, depression, and suicidal ideation may play a role in identifying an increased risk of mortality.
Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov 5 facts
claimLivingston G, Blizard B, and Mann A investigated whether sleep disturbance predicts depression in elderly people in a study conducted in inner London, published in the British Journal of General Practice in 1993.
claimSleep disturbances in Alzheimer’s disease are associated with behavioral symptoms including aggressiveness and depression, though the pathophysiology of this association is unknown.
claimAssociations between sleep disturbance and behavioral symptoms in Alzheimer’s disease patients include aggressiveness (Moran et al., 2005) and depression (Tractenberg et al., 2005).
claimAssociations between sleep disturbance and behavioral symptoms in Alzheimer’s disease patients include aggressiveness (Moran et al., 2005) and depression (Tractenberg et al., 2005).
claimCytokines used as biotherapy adjuncts, specifically interferon, interleukin-2, and tumor necrosis factor, are associated with side effects including daytime sleepiness, disturbed sleep, and depression.
How Sleep Deprivation Impacts Mental Health columbiapsychiatry.org 1 fact
claimSleep disturbances are linked to higher levels of psychological distress, and anxiety and depression rates were considerably higher than pre-pandemic levels in a study of 22,330 adults from 13 countries.
Understanding Male Hormonal Changes: A Complete Guide (2025) coremedicalwellness.com 1 fact
claimMental and emotional symptoms of hormonal imbalance in men include mood changes, irritability, depression, difficulty concentrating, brain fog, reduced motivation, reduced sense of well-being, and sleep disturbances.
Neuroscience of sleep - Wikipedia en.wikipedia.org 1 fact
claimShort-term consequences of sleep disruption in healthy individuals include increased stress responsivity and psychosocial issues, such as impaired cognitive or academic performance and depression.
Why At Least 7 Hours of Sleep Is Essential for Brain Health medicine.utah.edu 1 fact
claimSleep disturbances are associated with a higher risk of developing mood disorders, such as depression and anxiety.
The impact of childhood trauma on children's wellbeing and adult ... ouci.dntb.gov.ua 1 fact
claimThe relationship between adverse childhood experiences (ACEs) and sleep disturbances is mediated by stress and anxiety, but not by resilience or depression.
Hormonal Changes In Men As They Grow Older - Elderplan elderplan.org 1 fact
claimAdditional symptoms potentially associated with low testosterone include decreased energy and motivation, lack of confidence, poor concentration, depression, increased sleepiness, and sleep disturbances.