Knowledge Tree
Relations (1)
related 2.32 — strongly supporting 4 facts
The prefrontal cortex and nucleus accumbens are functionally linked through top-down modulation of striatal activity [1] and are both key components in emotion regulation circuits [2]. Furthermore, both regions exhibit shared neurobiological responses to chronic THC exposure [3] and pharmacological upregulation of neurotrophic factors like BDNF following ibogaine administration [4].
Facts (4)
Sources
Self-awareness, self-regulation, and self-transcendence (S-ART) frontiersin.org 2 facts
referenceBrain areas critical for their interactions with the prefrontal cortex (PFC) in emotion regulation include the amygdala, hippocampus, striatum (including the nucleus accumbens), thalamus, and insula.
claimActivity in the prefrontal cortex (PFC) can modulate ventral striatopallidum and nucleus accumbens activity in a top-down manner, providing a mechanism for tracking internally driven approach motivation (Heller et al., 2009) and regulating craving associated with phasic nucleus accumbens activity (Robbins and Everitt, 1996).
Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com 2 facts
claimChronic THC exposure during adolescence reduces BDNF levels via the CREB pathway in the hippocampus and prefrontal cortex of male rats, while paradoxically increasing BDNF in the nucleus accumbens of female rats.
measurementIbogaine administration at doses of 20 mg/kg and 40 mg/kg dose-dependently upregulated BDNF and NGF mRNA in the prefrontal cortex (PFC), ventral tegmental area (VTA), substantia nigra (SN), and nucleus accumbens (NAcc) of rat brains 24 hours post-injection, according to Marton et al. (2019).