obstructive sleep apnea ↔ sympathetic nervous system

Relations (1)

related 2.81 — strongly supporting 6 facts

Obstructive sleep apnea is linked to the sympathetic nervous system because the intermittent hypoxia and sleep fragmentation characteristic of the condition stimulate its activity [1], [2]. This activation leads to sustained physiological changes, including increased blood pressure and the release of catecholamines [3], [4], [5], [6].

Facts (6)

Sources

Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov Colten HR, Altevogt BM · National Academies Press 6 facts

measurementDuring the night, apneas and hypopneas associated with Obstructive Sleep Apnea (OSA) cause a transient rise in blood pressure of 30 mm Hg or more and increased activity of the sympathetic nervous system.

claimThe activation of the sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and adipocytes due to Obstructive Sleep Apnea (OSA) leads to the release of catecholamines, cortisol, and inflammatory cytokines, which may mediate the development of glucose intolerance, insulin resistance, and type 2 diabetes.

claimThe biochemical cascade by which Obstructive Sleep Apnea (OSA) disrupts glucose metabolism begins with intermittent hypoxia and recurrent sleep arousals (sleep fragmentation), which stimulate the sympathetic nervous system, the hypothalamic-pituitary-adrenal axis, and adipocytes.

claimThe transient blood pressure and sympathetic nervous system changes associated with Obstructive Sleep Apnea become sustained over time and are detectable during the daytime.

claimPunjabi and Beamer (2005) describe the biochemical cascade of obstructive sleep apnea (OSA) as beginning with intermittent hypoxia and recurrent sleep fragmentation, which stimulates the sympathetic nervous system, the hypothalamic-pituitary-adrenal axis, and adipocytes.

claimDuring the night, the apneas and hypopneas associated with Obstructive Sleep Apnea cause increased activity of the sympathetic nervous system.