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Relations (1)

related 2.32 — strongly supporting 4 facts

Cancer and senescence are linked through shared biological mechanisms like autophagy [1] and the regulatory role of pericentromeric noncoding RNA [2], with senescence being actively explored as a therapeutic strategy for treating cancer {fact:1, fact:4}.

Facts (4)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature 3 facts

referencePericentromeric noncoding RNA alters the DNA binding of CTCF and influences inflammatory gene expression in senescence and cancer, as reported in the 2021 paper 'Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer' published in the Proceedings of the National Academy of Sciences.

claimCancer cells can establish a senescence response, which allows for the potential exploitation of senescence as a strategy to treat cancer.

referenceSenescence can be exploited for the treatment of cancer.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 1 fact

claimAutophagy functions at the intersection of aging, senescence, and cancer.