concept

senescence

Facts (19)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 12 facts

claimCartilage deterioration is linked to the Senescence-Associated Secretory Phenotype (SASP), while age-related mitochondrial dysfunction and oxidative stress may cause senescence in joint tissue cells.

claimSenescence and immunoregulation play a role in the tumor microenvironment.

referenceSenescence of activated stellate cells limits liver fibrosis.

referencePericentromeric noncoding RNA alters the DNA binding of CTCF and influences inflammatory gene expression in senescence and cancer, as reported in the 2021 paper 'Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer' published in the Proceedings of the National Academy of Sciences.

referenceRapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence.

claimMethods for inducing senescence in tumors include chemotherapy, radiotherapy, cell cycle inhibition, and telomerase inhibition.

claimCancer cells can establish a senescence response, which allows for the potential exploitation of senescence as a strategy to treat cancer.

referenceSenescence in chronic wounds and potential targeted therapies were discussed by Ji et al. in Burns & Trauma (2022).

referenceSenotherapeutics can be used to target senescence in idiopathic pulmonary fibrosis.

referenceNoncoding RNAs control telomere homeostasis in senescence and aging, as discussed in the 2020 paper 'Noncoding RNAs controlling telomere homeostasis in senescence and aging' published in Trends in Molecular Medicine.

referenceSenescence can be exploited for the treatment of cancer.

referenceFafian-Labora and O’Loghlen (2020) reviewed classical and nonclassical intercellular communication mechanisms in senescence and ageing.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 6 facts

referenceYe G, Li J, Yu W, Xie Z, Zheng G, Liu W et al. reported in Experimental & Molecular Medicine (2023) that ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate mesenchymal stem cell (MSC) senescence and osteoarthritis progression.

referenceZhang et al. (2022) reported in Protein & Cell that FTO stabilizes MIS12 and counteracts senescence.

claimAutophagy functions at the intersection of aging, senescence, and cancer.

referenceLiu F. et al. published 'S-sulfhydration of SIRT3 combats BMSC senescence and ameliorates osteoporosis via stabilizing heterochromatic and mitochondrial homeostasis' in Pharmacological Research in 2023, identifying S-sulfhydration of SIRT3 as a mechanism to improve bone marrow mesenchymal stem cell (BMSC) health.

claimSenescence influences the tumor-immune landscape, which has implications for cancer immunotherapy.

referenceFang J, Chen Z, Lai X, Yin W, Guo Y, Zhang W et al. reported in Bioorganic Chemistry (2022) that mesenchymal stem cell-derived HIF-1α-overexpressed extracellular vesicles ameliorate hypoxia-induced pancreatic β cell apoptosis and senescence through activating YTHDF1-mediated protective autophagy.

Inflammation and aging: signaling pathways and intervention ... nature.com Nature Jun 8, 2023 1 fact

claimSeneQuest is a resource tool available at http://Senequest.net that assists in aging research by facilitating the discovery of genes associated with senescence.