prefrontal cortex ↔ non-human primate

Relations (1)

cross_type 2.58 — strongly supporting 5 facts

The prefrontal cortex is a primary focus of experimental protocols testing the Global Neuronal Workspace Theory, which specifically compares decoding performance and ignition signals between mice and non-human primates [1], [2], [3], [4], [5].

Facts (5)

Sources

Protocol for testing global neuronal workspace and integrated ... journals.plos.org PLOS ONE 5 facts

claimGlobal Neuronal Workspace Theory (GNWT) requires that decoder performance in the posterior parietal cortex (PPC) after prefrontal cortex (PFC) manipulation is lower in mice and different in non-human primates (NHPs) to be considered a successful test result.

procedureTo test the Global Neuronal Workspace Theory (GNWT) prediction that conscious processing is represented by an ignition signal in the prefrontal cortex (PFC) and posterior parietal cortex (PPC) just after stimulus onset, the protocol assesses whether average decoding performance generalization is above chance level in the stimulus onset window, defined as 250–500 ms after stimulus onset for non-human primates (NHPs) and 150–400 ms after stimulus onset for mice.

procedureTo test the location of conscious content, the researchers will assess average decoding performance in the prefrontal cortex (PFC), posterior parietal cortex (PPC), and content-dependent sensory regions during the stimulus onset window (250–500 ms post-stimulus for NHPs; 150–400 ms post-stimulus for mice) and the stimulus duration window.

claimGlobal Neuronal Workspace Theory (GNWT) predicts that decoding performance in the posterior parietal cortex (PPC) will be affected by prefrontal cortex (PFC) manipulation, with performance expected to be lower for mice and either higher or lower for non-human primates (NHPs), based on the inhibitory effect of the PFC manipulation.

procedureTo test the Global Neuronal Workspace Theory (GNWT) prediction that an ignition signal occurs after stimulus offset, the researchers will assess whether the spike rate in the Prefrontal Cortex (PFC) and Posterior Parietal Cortex (PPC) during the stimulus offset window (250–500 ms after stimulus offset for non-human primates, and 150–400 ms after stimulus offset for mice) is greater than the baseline spike rate (0–250 ms before stimulus onset) using t-tests and Bayesian t-tests.