prefrontal cortex ↔ mice

Relations (1)

related 2.32 — strongly supporting 4 facts

The prefrontal cortex and mice are related because researchers record and manipulate neuronal activity within the prefrontal cortex of mice during behavioral tasks to enable cross-species comparisons, as described in [1], [2], [3], and [4].

Facts (4)

Sources

Protocol for testing global neuronal workspace and integrated ... journals.plos.org PLOS ONE 4 facts

procedureThe researchers will manipulate prefrontal cortex activity on a trial-to-trial basis using electrical stimulation in non-human primates and optogenetic silencing in mice.

procedureTo enable cross-species comparisons, the study protocol involves non-human primates (NHPs) and mice viewing or listening to supra-threshold visual or auditory stimuli for variable durations in a go-nogo task that controls for report confounds, while recording neuronal responses from visual, auditory, posterior parietal, and/or prefrontal cortical areas using Neuropixels electrodes.

procedureNeuropixels probes are used to record spiking activity and LFPs simultaneously from two PFC areas, two sensory areas, and one parietal area in NHPs and mice during behavioral tasks.

procedureThe researchers will manipulate prefrontal cortex (PFC) activity from 0–0.5 seconds after stimulus onset in non-human primates and mice for irrelevant stimuli, using a single stimulus duration of 0.5 seconds.