Knowledge Tree
Relations (1)
related 2.58 — strongly supporting 5 facts
Obesity is intrinsically linked to adipose tissue through physiological changes, such as macrophage infiltration [1] and the induction of systemic inflammation [2]. Furthermore, the hormonal regulation of appetite is mediated by adipose tissue [3], and the two concepts are connected by the shared biological concept of 'adipaging' [4] and the study of their immune interplay [5].
Facts (5)
Sources
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 2 facts
claimObesity is associated with macrophage infiltration of adipose tissue, and the accumulation of macrophages in adipose tissue is directly proportional to the degree of obesity.
referenceExley MA, Hand L, O'Shea D, and Lynch L published a review titled 'Interplay between the immune system and adipose tissue in obesity' in the Journal of Endocrinology in 2014 (volume 223, issue 2, pages R41-48).
Chronic inflammation in the etiology of disease across the life span nature.com 1 fact
referenceAging and obesity share biological hallmarks related to dysfunctional adipose tissue, a concept termed 'adipaging', as described in a 2016 study in the Journal of Physiology.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 1 fact
claimAdipose tissue in obese or overweight individuals induces low-grade systemic inflammation.
Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov 1 fact
claimSleep insufficiency is associated with lower levels of leptin (an appetite-suppressing hormone produced by adipose tissue) and higher levels of ghrelin (a peptide that stimulates appetite), which suggests a hormonally mediated increase in appetite explains the link between short sleep and obesity (Taheri et al., 2004).