Knowledge Tree
Relations (1)
related 3.81 — strongly supporting 13 facts
Obesity is a primary cause and risk factor for chronic inflammation, as fat tissue functions as an endocrine organ that secretes pro-inflammatory cytokines {fact:1, fact:2, fact:3, fact:6, fact:10, fact:12}. Furthermore, obesity is characterized by a state of chronic, low-grade inflammation that contributes to metabolic dysfunction and insulin resistance {fact:8, fact:9, fact:11, fact:13}.
Facts (13)
Sources
Acute v chronic inflammation in the body: what's the difference? cbhs.com.au 2 facts
What Is Inflammation? Types, Causes & Treatment my.clevelandclinic.org 2 facts
claimCommon causes of chronic inflammation include low levels of physical activity, chronic stress, obesity (BMI at or above 30, especially visceral fat), gut dysbiosis, regular consumption of foods high in trans fat or salt, disrupted sleep and circadian rhythm, exposure to toxins (hazardous waste, industrial chemicals), tobacco use, and excessive alcohol consumption.
claimChronic inflammation is primarily caused by environmental factors, including daily life habits and toxin exposure, such as low physical activity, chronic stress, obesity (BMI of 30 or higher, particularly visceral fat), gut microbiome imbalance (dysbiosis), consumption of inflammatory foods (high trans fat or salt), disrupted sleep and circadian rhythm, exposure to toxins (hazardous waste, industrial chemicals), tobacco use, and excessive alcohol consumption.
How to reduce inflammation in the body - MD Anderson Cancer Center mdanderson.org 2 facts
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 2 facts
claimObesity is characterized by chronic, low-grade inflammation, which is considered an important contributor to the pathogenesis of insulin resistance.
referenceMraz M and Haluzik M published a review titled 'The role of adipose tissue immune cells in obesity and low-grade inflammation' in the Journal of Endocrinology in 2014 (volume 222, issue 3, pages R113-127).
Should you be tested for inflammation? health.harvard.edu 1 fact
claimMedical tests for inflammation cannot distinguish between acute inflammation, which may develop with a cold, pneumonia, or an injury, and chronic inflammation, which may accompany diabetes, obesity, or an autoimmune disease.
Understanding acute and chronic inflammation - Harvard Health health.harvard.edu 1 fact
claimRegular exercise can help protect against conditions linked with chronic inflammation, specifically heart disease and obesity.
Risk Factors: Chronic Inflammation - NCI - National Cancer Institute cancer.gov 1 fact
claimPotential causes of chronic inflammation include persistent infections, abnormal immune reactions to normal tissues, and conditions such as obesity.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 1 fact
claimObesity is a risk factor for chronic inflammation because fat tissue acts as an endocrine organ, secreting adipokines and inflammatory mediators, with body mass index being proportional to the amount of pro-inflammatory cytokines secreted, as exemplified by metabolic syndrome.
What is inflammation, and why is it dangerous? health.harvard.edu 1 fact
claimChronic inflammation can be triggered by exposure to toxins, chronic stress, obesity, and autoimmune disorders.