Knowledge Tree
Relations (1)
cross_type 2.58 — strongly supporting 5 facts
Bruce S. McEwen is the primary researcher who coined the term 'allostatic load' alongside Eliot Stellar [1] and subsequently developed its definition [2], theoretical framework [3], and mathematical formula [4]. He is also famously credited with describing the concept as the 'price of adaptation' [5].
Facts (5)
Sources
Allostasis revisited: A perception, variation, and risk framework frontiersin.org 4 facts
formulaIn the energetics-based framework proposed by Bruce McEwen and John Wingfield (2003), allostatic load is calculated as the function: allostatic load = Ee (basal existence) + Ei (routine activity) + Eo (unpredictable perturbations).
claimThe definition of allostatic load developed by Bruce McEwen and Stellar (1993) and elaborated by Bruce McEwen (1998) refers to specific pathologies associated with chronic stress, particularly chronic exposure to elevated glucocorticoid hormones in humans and laboratory animals.
quoteBruce McEwen described allostatic load as "the price of adaptation that promotes pathophysiology."
formulaBruce McEwen and John Wingfield developed an energetics-based framework for allostatic load in 2003, where allostatic load is a function of Ee (basal existence), Ei (routine activity), and Eo (unpredictable perturbations).
Understanding Allostasis: Stability Through Change - Cannelevate cannelevate.com.au 1 fact
claimBruce McEwen and Eliot Stellar coined the term "allostatic load" in 1993 to describe the physiological burden of ongoing adaptation and the strain produced by systems under challenge.