Knowledge Tree
Relations (1)
related 2.00 — strongly supporting 3 facts
The relationship between aging and NAD+ is established by research showing that NAD+ synthesis and levels are directly implicated in the aging process [1], with specific studies highlighting how CD38 expression increases during aging to regulate NAD+ levels [2] and how NAD+ synthesis influences immune function as organisms age [3].
Facts (3)
Sources
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 3 facts
referenceChini C.C.S. et al. published 'CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD(+) and NMN levels' in Nature Metabolism in 2020, establishing that CD38 expression increases during aging and impacts NAD+ and NMN levels.
referenceNAD+ levels are implicated in aging, metabolism, and neurodegeneration, as detailed by E. Verdin in a 2015 article in Science.
referenceMinhas P.S. et al. published 'Macrophage de novo NAD(+) synthesis specifies immune function in aging and inflammation' in Nature Immunology in 2019, detailing how NAD+ synthesis affects immune function.