Plasma cells ↔ macrophages

Relations (1)

related 2.58 — strongly supporting 5 facts

Macrophages and plasma cells are both identified as primary inflammatory cells that infiltrate tissue sites during chronic inflammation [1], [2], and [3]. Furthermore, they both contribute to the progression of tissue damage and repair processes through the production of inflammatory cytokines and enzymes [4], [3], while macrophages specifically produce cytokines that target and influence the differentiation of plasma cells [5].

Facts (5)

Sources

Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov National Library of Medicine 4 facts

claimChronic inflammation is characterized by the infiltration of primary inflammatory cells, specifically macrophages, lymphocytes, and plasma cells, into the tissue site.

claimNonspecific proliferative chronic inflammation is characterized by the presence of non-specific granulation tissue formed by the infiltration of mononuclear cells, such as lymphocytes, macrophages, and plasma cells, alongside the proliferation of fibroblasts, connective tissue, vessels, and epithelial cells, as seen in nasal or cervical polyps and lung abscesses.

claimIn chronic inflammation, infiltrating macrophages, lymphocytes, and plasma cells produce inflammatory cytokines, growth factors, and enzymes, which contribute to tissue damage progression and secondary repair processes such as fibrosis and granuloma formation.

claimThe hallmarks of chronic inflammation include the infiltration of primary inflammatory cells—specifically macrophages, lymphocytes, and plasma cells—into the tissue site, where they produce inflammatory cytokines, growth factors, and enzymes that contribute to tissue damage and secondary repair processes like fibrosis and granuloma formation.

Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com Thermo Fisher Scientific 1 fact

referenceIL-6 is classified as a pro-inflammatory cytokine, is produced by Th cells, macrophages, and fibroblasts, binds to CD126 and CD130 receptors, targets B cells and plasma cells, and functions in B-cell differentiation.