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DNA damage ↔ aging

Relations (1)

related 2.00 — strongly supporting 2 facts

The relationship between aging and DNA damage is established through academic research analyzing their causal link [1], [2], and the observation that DNA damage in pre-senescent cells directly increases sensitivity to the aging process [3].

Facts (2)

Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature 1 fact
referenceThe role of damage to DNA and other macromolecules in aging is discussed in the 2009 paper 'Does damage to DNA and other macromolecules play a role in aging? If so, how?' published in The Journals of Gerontology: Series A.
Hallmarks and mechanisms of cellular senescence in aging ... - Nature nature.com Nature 1 fact
referenceSchumacher B, Garinis GA, and Hoeijmakers JH analyzed the relationship between DNA damage and aging in a 2008 article in Trends in Genetics.